Anaphylaxis to clindamycin following cutaneous exposure

BACKGROUND: The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported. CASE PRESENTATION: We describe the first case of intravenous clindamycin anaphylaxis, w...

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Detalles Bibliográficos
Autores principales: Paradis, N., Marois, L., Paradis, L., Graham, F., Bégin, P., Des Roches, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304217/
https://www.ncbi.nlm.nih.gov/pubmed/32577121
http://dx.doi.org/10.1186/s13223-020-00452-y
Descripción
Sumario:BACKGROUND: The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported. CASE PRESENTATION: We describe the first case of intravenous clindamycin anaphylaxis, with likely sensitization due to previous topical exposure to clindamycin gel for acne in a 14-year-old boy with history of atopy and mild atopic dermatitis. CONCLUSION: This case highlights the potential sensitization to drug allergens, including antibiotics, via the skin.

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