TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter

BACKGROUND: As a lipid metabolic disorder, non-alcoholic fatty liver disease (NAFLD) is an important cause of cirrhosis and hepatocellular carcinoma, with no effective drug up to date. Previous studies have demonstrated increased methylation levels of key genes in NAFLD, suggesting that hydroxymethy...

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Detalles Bibliográficos
Autores principales: Wang, Jingjie, Zhang, Yitong, Zhuo, Qin, Tseng, Yujen, Wang, Jiucun, Ma, Yanyun, Zhang, Jun, Liu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304222/
https://www.ncbi.nlm.nih.gov/pubmed/32577122
http://dx.doi.org/10.1186/s12986-020-00466-8

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