Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant

The innate immune system allows for rapid recognition of pathogens. Toll-like receptor (TLR) signaling is a key aspect of the innate immune response, and interleukin-1 receptor-associated kinase 4 (IRAK4) plays a vital role in the TLR signaling cascade. Each TLR recognizes a distinct set of pathogen...

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Detalles Bibliográficos
Autores principales: Jia, Alicia, James, Elliot, Lu, Henry Y., Sharma, Mehul, Modi, Bhavi P., Biggs, Catherine M., Hildebrand, Kyla J., Chomyn, Alanna, Erdle, Stephanie, Kular, Hasandeep, Turvey, Stuart E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304365/
https://www.ncbi.nlm.nih.gov/pubmed/32532880
http://dx.doi.org/10.1101/mcs.a005298

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