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Overexpression of Adiponectin Receptors in Opium Users with and without Cancer

AIM: Opium addiction is a serious public health concern in the Middle East countries causing various illnesses. Opium use is associated with an increased risk of several cancers; however, the underlying mechanisms are not yet fully elucidated. Altered levels of adiponectin and its related main recep...

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Autores principales: Firouzabadi, Negar, Haghnegahdar, Maral, Khalvati, Bahman, Dehshahri, Ali, Bahramali, Ehsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304683/
https://www.ncbi.nlm.nih.gov/pubmed/32607004
http://dx.doi.org/10.2147/CPAA.S256289
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author Firouzabadi, Negar
Haghnegahdar, Maral
Khalvati, Bahman
Dehshahri, Ali
Bahramali, Ehsan
author_facet Firouzabadi, Negar
Haghnegahdar, Maral
Khalvati, Bahman
Dehshahri, Ali
Bahramali, Ehsan
author_sort Firouzabadi, Negar
collection PubMed
description AIM: Opium addiction is a serious public health concern in the Middle East countries causing various illnesses. Opium use is associated with an increased risk of several cancers; however, the underlying mechanisms are not yet fully elucidated. Altered levels of adiponectin and its related main receptors, Adiponectin receptor 1 and 2 (AdipoR1 and AdipoR2) have been associated with several malignancies. Opium users are at risk of various cancers. All together let us to the hypothesis that probable overexpression of AdipoRs in opium users might be linked to the occurrence of cancer in this population. METHODS: One hundred opium users along with 100 healthy non-opium users were enrolled in the study. Opium users were followed up for 5 years (2014–2019) to evaluate the occurrence of malignancies. AdipoR1 and AdipoR2 expressions were measured using a flow cytometry method. RESULTS: Expression of AdipoR1 and AdipoR2 was significantly higher in opium users compared with the healthy control group (P=0.0001 and 0.0001, respectively). Eight opium users developed cancer during the follow-up period. Subjects abusing opium developed cancer by 8.6 folds comparing to non-opium users (P=0.034; OR=8.6; 95% CI (1.06–70.1)). Expression of these two receptors was significantly higher in opium users developing cancer compared with cancer-free opium (P=0.001). CONCLUSION: Considering the significant overexpression of AdipoR1 and AdipoR2 in opium users and in opium users who developed malignancies and the association between upregulation of these receptors in most cancers affecting opium users and assessment of AdipoRs may serve as an early detection tool of cancer in this population.
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spelling pubmed-73046832020-06-29 Overexpression of Adiponectin Receptors in Opium Users with and without Cancer Firouzabadi, Negar Haghnegahdar, Maral Khalvati, Bahman Dehshahri, Ali Bahramali, Ehsan Clin Pharmacol Original Research AIM: Opium addiction is a serious public health concern in the Middle East countries causing various illnesses. Opium use is associated with an increased risk of several cancers; however, the underlying mechanisms are not yet fully elucidated. Altered levels of adiponectin and its related main receptors, Adiponectin receptor 1 and 2 (AdipoR1 and AdipoR2) have been associated with several malignancies. Opium users are at risk of various cancers. All together let us to the hypothesis that probable overexpression of AdipoRs in opium users might be linked to the occurrence of cancer in this population. METHODS: One hundred opium users along with 100 healthy non-opium users were enrolled in the study. Opium users were followed up for 5 years (2014–2019) to evaluate the occurrence of malignancies. AdipoR1 and AdipoR2 expressions were measured using a flow cytometry method. RESULTS: Expression of AdipoR1 and AdipoR2 was significantly higher in opium users compared with the healthy control group (P=0.0001 and 0.0001, respectively). Eight opium users developed cancer during the follow-up period. Subjects abusing opium developed cancer by 8.6 folds comparing to non-opium users (P=0.034; OR=8.6; 95% CI (1.06–70.1)). Expression of these two receptors was significantly higher in opium users developing cancer compared with cancer-free opium (P=0.001). CONCLUSION: Considering the significant overexpression of AdipoR1 and AdipoR2 in opium users and in opium users who developed malignancies and the association between upregulation of these receptors in most cancers affecting opium users and assessment of AdipoRs may serve as an early detection tool of cancer in this population. Dove 2020-06-15 /pmc/articles/PMC7304683/ /pubmed/32607004 http://dx.doi.org/10.2147/CPAA.S256289 Text en © 2020 Firouzabadi et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Firouzabadi, Negar
Haghnegahdar, Maral
Khalvati, Bahman
Dehshahri, Ali
Bahramali, Ehsan
Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_full Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_fullStr Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_full_unstemmed Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_short Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_sort overexpression of adiponectin receptors in opium users with and without cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304683/
https://www.ncbi.nlm.nih.gov/pubmed/32607004
http://dx.doi.org/10.2147/CPAA.S256289
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