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Inhibition of ERKs/Akt-Mediated c-Fos Expression Is Required for Piperlongumine-Induced Cyclin D1 Downregulation and Tumor Suppression in Colorectal Cancer Cells

BACKGROUND: Deregulation of Cyclin D1 and cell cycle progression plays a critical role in tumorigenesis. The natural compound piperlongumine (PL) exhibits potential anticancer effects in various cancer models, but the underlying mechanism needs further elucidation. METHODS: The inhibitory effect of...

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Detalles Bibliográficos
Autores principales:	Gao, Feng, Zhou, Li, Li, Ming, Liu, Wenbin, Yang, Shuting, Li, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304781/ https://www.ncbi.nlm.nih.gov/pubmed/32606774 http://dx.doi.org/10.2147/OTT.S251295

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