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Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative,...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304845/ https://www.ncbi.nlm.nih.gov/pubmed/32554617 http://dx.doi.org/10.1136/jitc-2020-000796 |
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author | Annapragada, Ananth Sikora, Andrew Bollard, Catherine Conejo-Garcia, Jose Cruz, Conrad Russell Demehri, Shadmehr Demetriou, Michael Demirdjian, Levon Fong, Lawrence Horowitz, Mary Hutson, Alan Kadash-Edmondson, Kathryn Kufe, Donald Lipkin, Steven Liu, Song McCarthy, Claire Morgan, Martin Morris, Zachary Pan, Yang Pasquini, Marcelo Schoenberger, Stephen Van Allen, Eliezer Vilar, Eduardo Xing, Yi Zha, Wenjuan Odunsi, Adekunle |
author_facet | Annapragada, Ananth Sikora, Andrew Bollard, Catherine Conejo-Garcia, Jose Cruz, Conrad Russell Demehri, Shadmehr Demetriou, Michael Demirdjian, Levon Fong, Lawrence Horowitz, Mary Hutson, Alan Kadash-Edmondson, Kathryn Kufe, Donald Lipkin, Steven Liu, Song McCarthy, Claire Morgan, Martin Morris, Zachary Pan, Yang Pasquini, Marcelo Schoenberger, Stephen Van Allen, Eliezer Vilar, Eduardo Xing, Yi Zha, Wenjuan Odunsi, Adekunle |
author_sort | Annapragada, Ananth |
collection | PubMed |
description | Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative, the Immuno-Oncology Translational Network (IOTN) was established to accelerate the translation of basic discoveries to improve immunotherapy outcomes across the spectrum of adult cancers and to develop immune-based approaches that prevent cancers before they occur. The IOTN currently consists of 32 academic institutions in the USA. By leveraging cutting-edge preclinical research in immunotherapy and immunoprevention, open data and resource sharing, and fostering highly collaborative team science across the immuno-oncology ecosystem, the IOTN is designed to accelerate the generation of novel mechanism-driven immune-based cancer prevention and therapies, and the development of safe and effective personalized immuno-oncology approaches. |
format | Online Article Text |
id | pubmed-7304845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-73048452020-06-22 Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer Annapragada, Ananth Sikora, Andrew Bollard, Catherine Conejo-Garcia, Jose Cruz, Conrad Russell Demehri, Shadmehr Demetriou, Michael Demirdjian, Levon Fong, Lawrence Horowitz, Mary Hutson, Alan Kadash-Edmondson, Kathryn Kufe, Donald Lipkin, Steven Liu, Song McCarthy, Claire Morgan, Martin Morris, Zachary Pan, Yang Pasquini, Marcelo Schoenberger, Stephen Van Allen, Eliezer Vilar, Eduardo Xing, Yi Zha, Wenjuan Odunsi, Adekunle J Immunother Cancer Review Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative, the Immuno-Oncology Translational Network (IOTN) was established to accelerate the translation of basic discoveries to improve immunotherapy outcomes across the spectrum of adult cancers and to develop immune-based approaches that prevent cancers before they occur. The IOTN currently consists of 32 academic institutions in the USA. By leveraging cutting-edge preclinical research in immunotherapy and immunoprevention, open data and resource sharing, and fostering highly collaborative team science across the immuno-oncology ecosystem, the IOTN is designed to accelerate the generation of novel mechanism-driven immune-based cancer prevention and therapies, and the development of safe and effective personalized immuno-oncology approaches. BMJ Publishing Group 2020-06-17 /pmc/articles/PMC7304845/ /pubmed/32554617 http://dx.doi.org/10.1136/jitc-2020-000796 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Annapragada, Ananth Sikora, Andrew Bollard, Catherine Conejo-Garcia, Jose Cruz, Conrad Russell Demehri, Shadmehr Demetriou, Michael Demirdjian, Levon Fong, Lawrence Horowitz, Mary Hutson, Alan Kadash-Edmondson, Kathryn Kufe, Donald Lipkin, Steven Liu, Song McCarthy, Claire Morgan, Martin Morris, Zachary Pan, Yang Pasquini, Marcelo Schoenberger, Stephen Van Allen, Eliezer Vilar, Eduardo Xing, Yi Zha, Wenjuan Odunsi, Adekunle Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
title | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
title_full | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
title_fullStr | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
title_full_unstemmed | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
title_short | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
title_sort | cancer moonshot immuno-oncology translational network (iotn): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304845/ https://www.ncbi.nlm.nih.gov/pubmed/32554617 http://dx.doi.org/10.1136/jitc-2020-000796 |
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