Cargando…

Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer

Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative,...

Descripción completa

Detalles Bibliográficos
Autores principales: Annapragada, Ananth, Sikora, Andrew, Bollard, Catherine, Conejo-Garcia, Jose, Cruz, Conrad Russell, Demehri, Shadmehr, Demetriou, Michael, Demirdjian, Levon, Fong, Lawrence, Horowitz, Mary, Hutson, Alan, Kadash-Edmondson, Kathryn, Kufe, Donald, Lipkin, Steven, Liu, Song, McCarthy, Claire, Morgan, Martin, Morris, Zachary, Pan, Yang, Pasquini, Marcelo, Schoenberger, Stephen, Van Allen, Eliezer, Vilar, Eduardo, Xing, Yi, Zha, Wenjuan, Odunsi, Adekunle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304845/
https://www.ncbi.nlm.nih.gov/pubmed/32554617
http://dx.doi.org/10.1136/jitc-2020-000796
_version_ 1783548340562034688
author Annapragada, Ananth
Sikora, Andrew
Bollard, Catherine
Conejo-Garcia, Jose
Cruz, Conrad Russell
Demehri, Shadmehr
Demetriou, Michael
Demirdjian, Levon
Fong, Lawrence
Horowitz, Mary
Hutson, Alan
Kadash-Edmondson, Kathryn
Kufe, Donald
Lipkin, Steven
Liu, Song
McCarthy, Claire
Morgan, Martin
Morris, Zachary
Pan, Yang
Pasquini, Marcelo
Schoenberger, Stephen
Van Allen, Eliezer
Vilar, Eduardo
Xing, Yi
Zha, Wenjuan
Odunsi, Adekunle
author_facet Annapragada, Ananth
Sikora, Andrew
Bollard, Catherine
Conejo-Garcia, Jose
Cruz, Conrad Russell
Demehri, Shadmehr
Demetriou, Michael
Demirdjian, Levon
Fong, Lawrence
Horowitz, Mary
Hutson, Alan
Kadash-Edmondson, Kathryn
Kufe, Donald
Lipkin, Steven
Liu, Song
McCarthy, Claire
Morgan, Martin
Morris, Zachary
Pan, Yang
Pasquini, Marcelo
Schoenberger, Stephen
Van Allen, Eliezer
Vilar, Eduardo
Xing, Yi
Zha, Wenjuan
Odunsi, Adekunle
author_sort Annapragada, Ananth
collection PubMed
description Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative, the Immuno-Oncology Translational Network (IOTN) was established to accelerate the translation of basic discoveries to improve immunotherapy outcomes across the spectrum of adult cancers and to develop immune-based approaches that prevent cancers before they occur. The IOTN currently consists of 32 academic institutions in the USA. By leveraging cutting-edge preclinical research in immunotherapy and immunoprevention, open data and resource sharing, and fostering highly collaborative team science across the immuno-oncology ecosystem, the IOTN is designed to accelerate the generation of novel mechanism-driven immune-based cancer prevention and therapies, and the development of safe and effective personalized immuno-oncology approaches.
format Online
Article
Text
id pubmed-7304845
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-73048452020-06-22 Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer Annapragada, Ananth Sikora, Andrew Bollard, Catherine Conejo-Garcia, Jose Cruz, Conrad Russell Demehri, Shadmehr Demetriou, Michael Demirdjian, Levon Fong, Lawrence Horowitz, Mary Hutson, Alan Kadash-Edmondson, Kathryn Kufe, Donald Lipkin, Steven Liu, Song McCarthy, Claire Morgan, Martin Morris, Zachary Pan, Yang Pasquini, Marcelo Schoenberger, Stephen Van Allen, Eliezer Vilar, Eduardo Xing, Yi Zha, Wenjuan Odunsi, Adekunle J Immunother Cancer Review Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative, the Immuno-Oncology Translational Network (IOTN) was established to accelerate the translation of basic discoveries to improve immunotherapy outcomes across the spectrum of adult cancers and to develop immune-based approaches that prevent cancers before they occur. The IOTN currently consists of 32 academic institutions in the USA. By leveraging cutting-edge preclinical research in immunotherapy and immunoprevention, open data and resource sharing, and fostering highly collaborative team science across the immuno-oncology ecosystem, the IOTN is designed to accelerate the generation of novel mechanism-driven immune-based cancer prevention and therapies, and the development of safe and effective personalized immuno-oncology approaches. BMJ Publishing Group 2020-06-17 /pmc/articles/PMC7304845/ /pubmed/32554617 http://dx.doi.org/10.1136/jitc-2020-000796 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Annapragada, Ananth
Sikora, Andrew
Bollard, Catherine
Conejo-Garcia, Jose
Cruz, Conrad Russell
Demehri, Shadmehr
Demetriou, Michael
Demirdjian, Levon
Fong, Lawrence
Horowitz, Mary
Hutson, Alan
Kadash-Edmondson, Kathryn
Kufe, Donald
Lipkin, Steven
Liu, Song
McCarthy, Claire
Morgan, Martin
Morris, Zachary
Pan, Yang
Pasquini, Marcelo
Schoenberger, Stephen
Van Allen, Eliezer
Vilar, Eduardo
Xing, Yi
Zha, Wenjuan
Odunsi, Adekunle
Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
title Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
title_full Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
title_fullStr Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
title_full_unstemmed Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
title_short Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
title_sort cancer moonshot immuno-oncology translational network (iotn): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304845/
https://www.ncbi.nlm.nih.gov/pubmed/32554617
http://dx.doi.org/10.1136/jitc-2020-000796
work_keys_str_mv AT annapragadaananth cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT sikoraandrew cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT bollardcatherine cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT conejogarciajose cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT cruzconradrussell cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT demehrishadmehr cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT demetrioumichael cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT demirdjianlevon cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT fonglawrence cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT horowitzmary cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT hutsonalan cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT kadashedmondsonkathryn cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT kufedonald cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT lipkinsteven cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT liusong cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT mccarthyclaire cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT morganmartin cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT morriszachary cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT panyang cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT pasquinimarcelo cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT schoenbergerstephen cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT vanalleneliezer cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT vilareduardo cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT xingyi cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT zhawenjuan cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer
AT odunsiadekunle cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer