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Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

[Image: see text] Neprilysin (NEP) and angiotensin-converting enzyme (ACE) are two key zinc-dependent metallopeptidases in the natriuretic peptide and kinin systems and renin–angiotensin–aldosterone system, respectively. They play an important role in blood pressure regulation and reducing the risk...

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Detalles Bibliográficos
Autores principales:	Sharma, Urvashi, Cozier, Gyles E., Sturrock, Edward D., Acharya, K. Ravi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304895/ https://www.ncbi.nlm.nih.gov/pubmed/32337993 http://dx.doi.org/10.1021/acs.jmedchem.0c00441

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