Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

Topoisomerase 3β (Top3β) is the only dual-activity topoisomerase in animals that can change topology for both DNA and RNA, and facilitate transcription on DNA and translation on mRNAs. Top3β mutations have been linked to schizophrenia, autism, epilepsy, and cognitive impairment. Here we show that To...

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Detalles Bibliográficos
Autores principales: Joo, Yuyoung, Xue, Yutong, Wang, Yue, McDevitt, Ross A., Sah, Nirnath, Bossi, Simone, Su, Shuaikun, Lee, Seung Kyu, Peng, Wei, Xie, Aoji, Zhang, Yongqing, Ding, Yi, Ku, Wai Lim, Ghosh, Soumita, Fishbein, Kenneth, Shen, Weiping, Spencer, Richard, Becker, Kevin, Zhao, Keji, Mattson, Mark P., van Praag, Henriette, Sharov, Alexei, Wang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305123/
https://www.ncbi.nlm.nih.gov/pubmed/32561719
http://dx.doi.org/10.1038/s41467-020-16884-4

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