Germline mutation rates in young adults predict longevity and reproductive lifespan

Ageing may be due to mutation accumulation across the lifespan, leading to tissue dysfunction, disease, and death. We tested whether germline autosomal mutation rates in young adults predict their remaining survival, and, for women, their reproductive lifespans. Age-adjusted mutation rates (AAMRs) i...

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Detalles Bibliográficos
Autores principales: Cawthon, Richard M., Meeks, Huong D., Sasani, Thomas A., Smith, Ken R., Kerber, Richard A., O’Brien, Elizabeth, Baird, Lisa, Dixon, Melissa M., Peiffer, Andreas P., Leppert, Mark F., Quinlan, Aaron R., Jorde, Lynn B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305191/
https://www.ncbi.nlm.nih.gov/pubmed/32561805
http://dx.doi.org/10.1038/s41598-020-66867-0

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