Exosomes: roles and therapeutic potential in osteoarthritis

Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis (OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint ce...

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Autores principales: Ni, Zhenhong, Zhou, Siru, Li, Song, Kuang, Liang, Chen, Hangang, Luo, Xiaoqing, Ouyang, Junjie, He, Mei, Du, Xiaolan, Chen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305215/
https://www.ncbi.nlm.nih.gov/pubmed/32596023
http://dx.doi.org/10.1038/s41413-020-0100-9
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author Ni, Zhenhong
Zhou, Siru
Li, Song
Kuang, Liang
Chen, Hangang
Luo, Xiaoqing
Ouyang, Junjie
He, Mei
Du, Xiaolan
Chen, Lin
author_facet Ni, Zhenhong
Zhou, Siru
Li, Song
Kuang, Liang
Chen, Hangang
Luo, Xiaoqing
Ouyang, Junjie
He, Mei
Du, Xiaolan
Chen, Lin
author_sort Ni, Zhenhong
collection PubMed
description Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis (OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling. This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future.
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spelling pubmed-73052152020-06-26 Exosomes: roles and therapeutic potential in osteoarthritis Ni, Zhenhong Zhou, Siru Li, Song Kuang, Liang Chen, Hangang Luo, Xiaoqing Ouyang, Junjie He, Mei Du, Xiaolan Chen, Lin Bone Res Review Article Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis (OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling. This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future. Nature Publishing Group UK 2020-06-19 /pmc/articles/PMC7305215/ /pubmed/32596023 http://dx.doi.org/10.1038/s41413-020-0100-9 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Ni, Zhenhong
Zhou, Siru
Li, Song
Kuang, Liang
Chen, Hangang
Luo, Xiaoqing
Ouyang, Junjie
He, Mei
Du, Xiaolan
Chen, Lin
Exosomes: roles and therapeutic potential in osteoarthritis
title Exosomes: roles and therapeutic potential in osteoarthritis
title_full Exosomes: roles and therapeutic potential in osteoarthritis
title_fullStr Exosomes: roles and therapeutic potential in osteoarthritis
title_full_unstemmed Exosomes: roles and therapeutic potential in osteoarthritis
title_short Exosomes: roles and therapeutic potential in osteoarthritis
title_sort exosomes: roles and therapeutic potential in osteoarthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305215/
https://www.ncbi.nlm.nih.gov/pubmed/32596023
http://dx.doi.org/10.1038/s41413-020-0100-9
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