Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling

Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC lo...

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Detalles Bibliográficos
Autores principales: Lin, Kun-Yang, Wang, Wen-Der, Lin, Chi-Hung, Rastegari, Elham, Su, Yu-Han, Chang, Yu-Tzu, Liao, Yung-Feng, Chang, Yi-Chieh, Pi, Haiwei, Yu, Bo-Yi, Chen, Shu-Hwa, Lin, Chung-Yen, Lu, Mei-Yeh, Su, Tsu-Yi, Tzou, Fei-Yang, Chan, Chih-Chiang, Hsu, Hwei-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305233/
https://www.ncbi.nlm.nih.gov/pubmed/32561720
http://dx.doi.org/10.1038/s41467-020-16858-6

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