Cargando…

Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB(2)-AcpM(2)

Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA) to its arabinosyl acceptor is an essential enzyme for Mtb c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Lu, Zhao, Yao, Gao, Ruogu, Li, Jun, Yang, Xiuna, Gao, Yan, Zhao, Wei, Gurcha, Sudagar S., Veerapen, Natacha, Batt, Sarah M., Besra, Kajelle Kaur, Xu, Wenqing, Bi, Lijun, Zhang, Xian’en, Guddat, Luke W., Yang, Haitao, Wang, Quan, Besra, Gurdyal S., Rao, Zihe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305291/ https://www.ncbi.nlm.nih.gov/pubmed/32363534 http://dx.doi.org/10.1007/s13238-020-00726-6

Ejemplares similares

Structure of the priming arabinosyltransferase AftA required for AG biosynthesis of Mycobacterium tuberculosis
por: Gong, Yicheng, et al.
Publicado: (2023)

Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis
por: Tan, Yong Zi, et al.
Publicado: (2020)

DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid
por: Abrahams, Katherine A., et al.
Publicado: (2023)

The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module
por: Alderwick, Luke J., et al.
Publicado: (2011)

EmbA is an essential arabinosyltransferase in Mycobacterium tuberculosis
por: Amin, Anita G., et al.
Publicado: (2008)

Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics
por: Trunkfield, Amy E., et al.
Publicado: (2010)

The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesis
por: Jankute, Monika, et al.
Publicado: (2018)

Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis
por: Usha, Veeraraghavan, et al.
Publicado: (2012)

Ppm1-Encoded Polyprenyl Monophosphomannose Synthase Activity Is Essential for Lipoglycan Synthesis and Survival in Mycobacteria
por: Rana, Amrita K., et al.
Publicado: (2012)

Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China
por: Shi, Dawei, et al.
Publicado: (2011)

Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases
por: Brown, Alistair K., et al.
Publicado: (2009)

Mutations in the embB Gene and Their Association with Ethambutol Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates from Poland
por: Bakuła, Zofia, et al.
Publicado: (2013)

Frequency of Codon 306 Mutations in embB Gene of Mycobacterium tuberculosis Resistant to Ethambutol: A Systematic Review and Meta-Analysis
por: Mohammadi, Bahman, et al.
Publicado: (2020)

Acceptor Substrate Discrimination in Phosphatidyl-myo-inositol Mannoside Synthesis: STRUCTURAL AND MUTATIONAL ANALYSIS OF MANNOSYLTRANSFERASE CORYNEBACTERIUM GLUTAMICUM PimB′
por: Batt, Sarah M., et al.
Publicado: (2010)

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
por: Batt, Sarah M., et al.
Publicado: (2020)

Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation
por: Veerapen, Natacha, et al.
Publicado: (2011)

Calreticulin Controls the Rate of Assembly of CD1d Molecules in the Endoplasmic Reticulum
por: Zhu, Yajuan, et al.
Publicado: (2010)

Detection of Beijing strains of MDR M. tuberculosis and their association with drug resistance mutations in katG, rpoB, and embB genes
por: Gupta, Anamika, et al.
Publicado: (2020)

A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis
por: Li, Mengmiao, et al.
Publicado: (2022)

Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB′ mutant
por: Mishra, Arun K., et al.
Publicado: (2008)

Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production
por: Dao, Dee N., et al.
Publicado: (2008)

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis
por: Sambandan, Dhinakaran, et al.
Publicado: (2013)

Synthesis and biological activity of α-l-fucosyl ceramides, analogues of the potent agonist, α-d-galactosyl ceramide KRN7000
por: Veerapen, Natacha, et al.
Publicado: (2010)

NSC19723, a Thiacetazone-Like Benzaldehyde Thiosemicarbazone Improves the Efficacy of TB Drugs In Vitro and In Vivo
por: Singh, Padam, et al.
Publicado: (2022)

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes
por: Ivanova, Irina M., et al.
Publicado: (2017)

Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan
por: Jankute, Monika, et al.
Publicado: (2016)

Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall
por: Batt, Sarah M., et al.
Publicado: (2020)

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis
por: Kendall, Sharon L, et al.
Publicado: (2007)

Synthesis and biological activity of α-glucosyl C24:0 and C20:2 ceramides
por: Jervis, Peter J., et al.
Publicado: (2010)

Endoplasmic Reticulum Glycoprotein Quality Control Regulates CD1d Assembly and CD1d-mediated Antigen Presentation
por: Kunte, Amit, et al.
Publicado: (2013)

Vanoxerine kills mycobacteria through membrane depolarization and efflux inhibition
por: Kingdon, Alexander D. H., et al.
Publicado: (2023)

The relationship between embb306 and embb406 mutations and ethambutol resistant in Mycobacterium tuberculosis isolated from patiens in west of Iran
por: Mohammadi, Bahman, et al.
Publicado: (2018)

Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide
por: Veerapen, Natacha, et al.
Publicado: (2009)

Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis
por: Batt, Sarah M., et al.
Publicado: (2023)

The History, present state, and future prospects of the Asian College of Psychosomatic Medicine (ACPM)
por: Ishizu, Hiroshi
Publicado: (2012)

Comment on: Characterization of the embB gene in Mycobacterium tuberculosis isolates from Barcelona and rapid detection of main mutations related to ethambutol resistance using a low-density DNA array
por: Köser, Claudio U., et al.
Publicado: (2014)

Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone
por: Muppidi, Jagan R., et al.
Publicado: (2011)

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component
por: Stoop, Esther J. M., et al.
Publicado: (2011)

Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target
por: ABRAHAMS, KATHERINE A., et al.
Publicado: (2018)

Synthesis and recycling of the mycobacterial cell envelope
por: Abrahams, Katherine A, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gcn5m1sf4mq5hhstnobhsuli5e