Repurposing type I–F CRISPR–Cas system as a transcriptional activation tool in human cells

Class 2 CRISPR–Cas proteins have been widely developed as genome editing and transcriptional regulating tools. Class 1 type I CRISPR–Cas constitutes ~60% of all the CRISPR–Cas systems. However, only type I–B and I–E systems have been used to control mammalian gene expression and for genome editing....

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Detalles Bibliográficos
Autores principales: Chen, Yuxi, Liu, Jiaqi, Zhi, Shengyao, Zheng, Qi, Ma, Wenbin, Huang, Junjiu, Liu, Yizhi, Liu, Dan, Liang, Puping, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305327/
https://www.ncbi.nlm.nih.gov/pubmed/32561716
http://dx.doi.org/10.1038/s41467-020-16880-8

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