Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone

Kikuchi-Fujimoto disease (KFD) is thought to be a self-limited disease featuring fever and cervical lymphadenopathy; most cases having a favorable outcome. Severe disease and death are occasionally reported. Here we report a case of KFD complicated by hemophagocytosis and aseptic meningitis. The sym...

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Detalles Bibliográficos
Autores principales: Huang, Xiaoyan, Chen, Xixi, Tong, Sun-Wing, Wang, Yan, Cai, Jifu, Deng, Chaowen, Zhang, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305385/
https://www.ncbi.nlm.nih.gov/pubmed/32577568
http://dx.doi.org/10.1016/j.heliyon.2020.e04193
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author Huang, Xiaoyan
Chen, Xixi
Tong, Sun-Wing
Wang, Yan
Cai, Jifu
Deng, Chaowen
Zhang, Lijun
author_facet Huang, Xiaoyan
Chen, Xixi
Tong, Sun-Wing
Wang, Yan
Cai, Jifu
Deng, Chaowen
Zhang, Lijun
author_sort Huang, Xiaoyan
collection PubMed
description Kikuchi-Fujimoto disease (KFD) is thought to be a self-limited disease featuring fever and cervical lymphadenopathy; most cases having a favorable outcome. Severe disease and death are occasionally reported. Here we report a case of KFD complicated by hemophagocytosis and aseptic meningitis. The symptoms and laboratory parameters improved after systemic glucocorticoids, intravenous immunoglobulin and one dose of intrathecal dexamethasone. Clinicians should aware of this disease and make early diagnosis by lymph node biopsy to avoid over-treatment.
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spelling pubmed-73053852020-06-22 Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone Huang, Xiaoyan Chen, Xixi Tong, Sun-Wing Wang, Yan Cai, Jifu Deng, Chaowen Zhang, Lijun Heliyon Article Kikuchi-Fujimoto disease (KFD) is thought to be a self-limited disease featuring fever and cervical lymphadenopathy; most cases having a favorable outcome. Severe disease and death are occasionally reported. Here we report a case of KFD complicated by hemophagocytosis and aseptic meningitis. The symptoms and laboratory parameters improved after systemic glucocorticoids, intravenous immunoglobulin and one dose of intrathecal dexamethasone. Clinicians should aware of this disease and make early diagnosis by lymph node biopsy to avoid over-treatment. Elsevier 2020-06-18 /pmc/articles/PMC7305385/ /pubmed/32577568 http://dx.doi.org/10.1016/j.heliyon.2020.e04193 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Huang, Xiaoyan
Chen, Xixi
Tong, Sun-Wing
Wang, Yan
Cai, Jifu
Deng, Chaowen
Zhang, Lijun
Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone
title Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone
title_full Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone
title_fullStr Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone
title_full_unstemmed Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone
title_short Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone
title_sort kikuchi-fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305385/
https://www.ncbi.nlm.nih.gov/pubmed/32577568
http://dx.doi.org/10.1016/j.heliyon.2020.e04193
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