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Confirmed E-cigarette or vaping product use associated lung injury (EVALI) with lung biopsy; A case report and literature review

BACKGROUND: E-cigarette or vaping has become an increasingly popular alternative to smoking tobacco. In September 2019 multiple cases of confirmed E-cigarette or vaping product use associated lung injury were published. However, there is limited knowledge regarding the pathologic mechanism of this c...

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Autores principales: Cedano, Jorge, Sah, Anuraag, Cedeno-Mendoza, Ricardo, Fish, Heidi, Remolina, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305409/
https://www.ncbi.nlm.nih.gov/pubmed/32577363
http://dx.doi.org/10.1016/j.rmcr.2020.101122
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author Cedano, Jorge
Sah, Anuraag
Cedeno-Mendoza, Ricardo
Fish, Heidi
Remolina, Carlos
author_facet Cedano, Jorge
Sah, Anuraag
Cedeno-Mendoza, Ricardo
Fish, Heidi
Remolina, Carlos
author_sort Cedano, Jorge
collection PubMed
description BACKGROUND: E-cigarette or vaping has become an increasingly popular alternative to smoking tobacco. In September 2019 multiple cases of confirmed E-cigarette or vaping product use associated lung injury were published. However, there is limited knowledge regarding the pathologic mechanism of this condition. METHODS: We performed a systematic literature review in PubMed and EMBASE aiming to obtain additional clinical data on confirmed E-cigarette or vaping product use associated lung injury cases with lung biopsy results. With this information we hope to determine whether this condition is related to a histopathological pattern of acute lung injury instead of lipid deposits. RESULTS: Seven articles were reviewed and a total of 27 cases were included. Imaging findings predominantly showed presence of diffuse bilateral ground glass opacities. A majority of patients had complete resolution of the disease. The most common histopathological pattern was organizing pneumonia present in almost half of the patients. Other frequently occurring patterns included diffuse alveolar damage and acute fibrinous pneumonitis; lipoid pneumonia was found in one case. CONCLUSION: The underlying pathophysiological mechanism in E-cigarette or vaping product use associated lung injury is most likely acute lung injury related to direct inhalant-mediated parenchymal inflammation.
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spelling pubmed-73054092020-06-22 Confirmed E-cigarette or vaping product use associated lung injury (EVALI) with lung biopsy; A case report and literature review Cedano, Jorge Sah, Anuraag Cedeno-Mendoza, Ricardo Fish, Heidi Remolina, Carlos Respir Med Case Rep Case Report BACKGROUND: E-cigarette or vaping has become an increasingly popular alternative to smoking tobacco. In September 2019 multiple cases of confirmed E-cigarette or vaping product use associated lung injury were published. However, there is limited knowledge regarding the pathologic mechanism of this condition. METHODS: We performed a systematic literature review in PubMed and EMBASE aiming to obtain additional clinical data on confirmed E-cigarette or vaping product use associated lung injury cases with lung biopsy results. With this information we hope to determine whether this condition is related to a histopathological pattern of acute lung injury instead of lipid deposits. RESULTS: Seven articles were reviewed and a total of 27 cases were included. Imaging findings predominantly showed presence of diffuse bilateral ground glass opacities. A majority of patients had complete resolution of the disease. The most common histopathological pattern was organizing pneumonia present in almost half of the patients. Other frequently occurring patterns included diffuse alveolar damage and acute fibrinous pneumonitis; lipoid pneumonia was found in one case. CONCLUSION: The underlying pathophysiological mechanism in E-cigarette or vaping product use associated lung injury is most likely acute lung injury related to direct inhalant-mediated parenchymal inflammation. Elsevier 2020-06-11 /pmc/articles/PMC7305409/ /pubmed/32577363 http://dx.doi.org/10.1016/j.rmcr.2020.101122 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Cedano, Jorge
Sah, Anuraag
Cedeno-Mendoza, Ricardo
Fish, Heidi
Remolina, Carlos
Confirmed E-cigarette or vaping product use associated lung injury (EVALI) with lung biopsy; A case report and literature review
title Confirmed E-cigarette or vaping product use associated lung injury (EVALI) with lung biopsy; A case report and literature review
title_full Confirmed E-cigarette or vaping product use associated lung injury (EVALI) with lung biopsy; A case report and literature review
title_fullStr Confirmed E-cigarette or vaping product use associated lung injury (EVALI) with lung biopsy; A case report and literature review
title_full_unstemmed Confirmed E-cigarette or vaping product use associated lung injury (EVALI) with lung biopsy; A case report and literature review
title_short Confirmed E-cigarette or vaping product use associated lung injury (EVALI) with lung biopsy; A case report and literature review
title_sort confirmed e-cigarette or vaping product use associated lung injury (evali) with lung biopsy; a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305409/
https://www.ncbi.nlm.nih.gov/pubmed/32577363
http://dx.doi.org/10.1016/j.rmcr.2020.101122
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