Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery

Hypoxic pulmonary hypertension (HPH) is a devastating disease characterized by progressive vasoconstriction and vascular remodeling. Pirfenidone (PFD) inhibits the progression of HPH, though the molecular mechanisms remain unknown. This study is aimed at determining the role and mechanism of PFD in...

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Detalles Bibliográficos
Autores principales: Zhang, Song, Yin, ZongXiu, Qin, WeiDong, Ma, XiaoLi, Zhang, Yao, Liu, EnXiu, Chu, YanBiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305537/
https://www.ncbi.nlm.nih.gov/pubmed/32587469
http://dx.doi.org/10.1155/2020/2604967

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