Current Status of COVID-19 Therapies and Drug Repositioning Applications

The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to tr...

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Autores principales: Altay, Ozlem, Mohammadi, Elyas, Lam, Simon, Turkez, Hasan, Boren, Jan, Nielsen, Jens, Uhlen, Mathias, Mardinoglu, Adil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305759/
https://www.ncbi.nlm.nih.gov/pubmed/32622261
http://dx.doi.org/10.1016/j.isci.2020.101303
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author Altay, Ozlem
Mohammadi, Elyas
Lam, Simon
Turkez, Hasan
Boren, Jan
Nielsen, Jens
Uhlen, Mathias
Mardinoglu, Adil
author_facet Altay, Ozlem
Mohammadi, Elyas
Lam, Simon
Turkez, Hasan
Boren, Jan
Nielsen, Jens
Uhlen, Mathias
Mardinoglu, Adil
author_sort Altay, Ozlem
collection PubMed
description The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.
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spelling pubmed-73057592020-06-22 Current Status of COVID-19 Therapies and Drug Repositioning Applications Altay, Ozlem Mohammadi, Elyas Lam, Simon Turkez, Hasan Boren, Jan Nielsen, Jens Uhlen, Mathias Mardinoglu, Adil iScience Review The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2. Elsevier 2020-06-20 /pmc/articles/PMC7305759/ /pubmed/32622261 http://dx.doi.org/10.1016/j.isci.2020.101303 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Altay, Ozlem
Mohammadi, Elyas
Lam, Simon
Turkez, Hasan
Boren, Jan
Nielsen, Jens
Uhlen, Mathias
Mardinoglu, Adil
Current Status of COVID-19 Therapies and Drug Repositioning Applications
title Current Status of COVID-19 Therapies and Drug Repositioning Applications
title_full Current Status of COVID-19 Therapies and Drug Repositioning Applications
title_fullStr Current Status of COVID-19 Therapies and Drug Repositioning Applications
title_full_unstemmed Current Status of COVID-19 Therapies and Drug Repositioning Applications
title_short Current Status of COVID-19 Therapies and Drug Repositioning Applications
title_sort current status of covid-19 therapies and drug repositioning applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305759/
https://www.ncbi.nlm.nih.gov/pubmed/32622261
http://dx.doi.org/10.1016/j.isci.2020.101303
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