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COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential
BACKGROUND: Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8(+) T and NK cells in COVID-19 patients. METHODS: The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305921/ https://www.ncbi.nlm.nih.gov/pubmed/32574709 http://dx.doi.org/10.1016/j.clim.2020.108516 |
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author | Jiang, Yujie Wei, Xin Guan, Jingjing Qin, Shuang Wang, Zhongyong Lu, Hong Qian, Jingjing Wu, Lianfeng Chen, Yingxiao Chen, Yanfan Lin, Xiangyang |
author_facet | Jiang, Yujie Wei, Xin Guan, Jingjing Qin, Shuang Wang, Zhongyong Lu, Hong Qian, Jingjing Wu, Lianfeng Chen, Yingxiao Chen, Yanfan Lin, Xiangyang |
author_sort | Jiang, Yujie |
collection | PubMed |
description | BACKGROUND: Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8(+) T and NK cells in COVID-19 patients. METHODS: The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals. RESULTS: As the disease progression in COVID-19 patients, CD8(+) T and NK cells were significantly decreased in absolute number but highly activated. After patients' condition improved, the count and immune status of CD8(+) T and NK cells restored to some extent. GrA(+)CD8(+) T and perforin(+) NK cells had good sensitivity and specificity for assisting diagnosis of COVID-19. CONCLUSIONS: As the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8(+) T and NK cells. GrA(+)CD8(+) T and perforin(+) NK cells might be used as meaningful indicators for assisting diagnosis of COVID-19. |
format | Online Article Text |
id | pubmed-7305921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73059212020-06-22 COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential Jiang, Yujie Wei, Xin Guan, Jingjing Qin, Shuang Wang, Zhongyong Lu, Hong Qian, Jingjing Wu, Lianfeng Chen, Yingxiao Chen, Yanfan Lin, Xiangyang Clin Immunol Article BACKGROUND: Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8(+) T and NK cells in COVID-19 patients. METHODS: The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals. RESULTS: As the disease progression in COVID-19 patients, CD8(+) T and NK cells were significantly decreased in absolute number but highly activated. After patients' condition improved, the count and immune status of CD8(+) T and NK cells restored to some extent. GrA(+)CD8(+) T and perforin(+) NK cells had good sensitivity and specificity for assisting diagnosis of COVID-19. CONCLUSIONS: As the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8(+) T and NK cells. GrA(+)CD8(+) T and perforin(+) NK cells might be used as meaningful indicators for assisting diagnosis of COVID-19. Published by Elsevier Inc. 2020-09 2020-06-20 /pmc/articles/PMC7305921/ /pubmed/32574709 http://dx.doi.org/10.1016/j.clim.2020.108516 Text en © 2020 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Jiang, Yujie Wei, Xin Guan, Jingjing Qin, Shuang Wang, Zhongyong Lu, Hong Qian, Jingjing Wu, Lianfeng Chen, Yingxiao Chen, Yanfan Lin, Xiangyang COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential |
title | COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential |
title_full | COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential |
title_fullStr | COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential |
title_full_unstemmed | COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential |
title_short | COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential |
title_sort | covid-19 pneumonia: cd8(+) t and nk cells are decreased in number but compensatory increased in cytotoxic potential |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305921/ https://www.ncbi.nlm.nih.gov/pubmed/32574709 http://dx.doi.org/10.1016/j.clim.2020.108516 |
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