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Fatal SARS-CoV-2 infection in a renal transplant recipient

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) caused a pandemic that first discovered in Wuhan, China. While 10% of the patients have asymptomatic infection, 15–20% have lung involvement, 5–10% have multiple organ failure, and macrophage activation syndrome. Chronic respiratory di...

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Autores principales: Dirim, Ahmet Burak, Demir, Erol, Ucar, Ali Riza, Garayeva, Nurana, Safak, Seda, Oto, Ozgur Akin, Yazici, Halil, Alibeyoglu, Alpay Medet, Orhun, Gunseli, Cagatay, Arif Atahan, Turkmen, Aydin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305930/
https://www.ncbi.nlm.nih.gov/pubmed/32564306
http://dx.doi.org/10.1007/s13730-020-00496-4
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author Dirim, Ahmet Burak
Demir, Erol
Ucar, Ali Riza
Garayeva, Nurana
Safak, Seda
Oto, Ozgur Akin
Yazici, Halil
Alibeyoglu, Alpay Medet
Orhun, Gunseli
Cagatay, Arif Atahan
Turkmen, Aydin
author_facet Dirim, Ahmet Burak
Demir, Erol
Ucar, Ali Riza
Garayeva, Nurana
Safak, Seda
Oto, Ozgur Akin
Yazici, Halil
Alibeyoglu, Alpay Medet
Orhun, Gunseli
Cagatay, Arif Atahan
Turkmen, Aydin
author_sort Dirim, Ahmet Burak
collection PubMed
description The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) caused a pandemic that first discovered in Wuhan, China. While 10% of the patients have asymptomatic infection, 15–20% have lung involvement, 5–10% have multiple organ failure, and macrophage activation syndrome. Chronic respiratory diseases, diabetes mellitus, hypertension, and cancer are risk factors for mortality. Prognosis or optimal treatment strategy for renal transplant recipients in SARS-CoV-2 infection is still unknown. Besides fatal cases, there were also milder case reports. In addition, COVID-19 treatment and the maintenance immunosuppression strategy is still under debate. Antiviral therapies and drug interactions are special topics for these patients. To the best of our knowledge, favipiravir and anti-cytokine treatments have not been previously reported in a kidney transplant recipient with SARS-CoV-2 infection before. We report a case of SARS-CoV-2 infection in a kidney transplant recipient with fatal outcomes.
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spelling pubmed-73059302020-06-22 Fatal SARS-CoV-2 infection in a renal transplant recipient Dirim, Ahmet Burak Demir, Erol Ucar, Ali Riza Garayeva, Nurana Safak, Seda Oto, Ozgur Akin Yazici, Halil Alibeyoglu, Alpay Medet Orhun, Gunseli Cagatay, Arif Atahan Turkmen, Aydin CEN Case Rep Case Report The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) caused a pandemic that first discovered in Wuhan, China. While 10% of the patients have asymptomatic infection, 15–20% have lung involvement, 5–10% have multiple organ failure, and macrophage activation syndrome. Chronic respiratory diseases, diabetes mellitus, hypertension, and cancer are risk factors for mortality. Prognosis or optimal treatment strategy for renal transplant recipients in SARS-CoV-2 infection is still unknown. Besides fatal cases, there were also milder case reports. In addition, COVID-19 treatment and the maintenance immunosuppression strategy is still under debate. Antiviral therapies and drug interactions are special topics for these patients. To the best of our knowledge, favipiravir and anti-cytokine treatments have not been previously reported in a kidney transplant recipient with SARS-CoV-2 infection before. We report a case of SARS-CoV-2 infection in a kidney transplant recipient with fatal outcomes. Springer Singapore 2020-06-20 /pmc/articles/PMC7305930/ /pubmed/32564306 http://dx.doi.org/10.1007/s13730-020-00496-4 Text en © Japanese Society of Nephrology 2020
spellingShingle Case Report
Dirim, Ahmet Burak
Demir, Erol
Ucar, Ali Riza
Garayeva, Nurana
Safak, Seda
Oto, Ozgur Akin
Yazici, Halil
Alibeyoglu, Alpay Medet
Orhun, Gunseli
Cagatay, Arif Atahan
Turkmen, Aydin
Fatal SARS-CoV-2 infection in a renal transplant recipient
title Fatal SARS-CoV-2 infection in a renal transplant recipient
title_full Fatal SARS-CoV-2 infection in a renal transplant recipient
title_fullStr Fatal SARS-CoV-2 infection in a renal transplant recipient
title_full_unstemmed Fatal SARS-CoV-2 infection in a renal transplant recipient
title_short Fatal SARS-CoV-2 infection in a renal transplant recipient
title_sort fatal sars-cov-2 infection in a renal transplant recipient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305930/
https://www.ncbi.nlm.nih.gov/pubmed/32564306
http://dx.doi.org/10.1007/s13730-020-00496-4
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