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Determinants of Drug-Resistant Tuberculosis in Southern Ethiopia: A Case–Control Study

BACKGROUND: In most developing countries, including in Ethiopia, the magnitude and risk factors of drug-resistant tuberculosis (DR-TB) are expected to be high. However, this is not well reported because of lack of laboratory facilities, poor surveillance system and limited reporting. The aim of this...

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Autores principales: Biru, Daniel, Woldesemayat, Endrias Markos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305943/
https://www.ncbi.nlm.nih.gov/pubmed/32606831
http://dx.doi.org/10.2147/IDR.S256536
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author Biru, Daniel
Woldesemayat, Endrias Markos
author_facet Biru, Daniel
Woldesemayat, Endrias Markos
author_sort Biru, Daniel
collection PubMed
description BACKGROUND: In most developing countries, including in Ethiopia, the magnitude and risk factors of drug-resistant tuberculosis (DR-TB) are expected to be high. However, this is not well reported because of lack of laboratory facilities, poor surveillance system and limited reporting. The aim of this study was to determine the risk factors of DR-TB among TB patients in southern Ethiopia. PATIENTS AND METHODS: Facility-based case–control study was conducted from November 2016 to January 2017 in Sidama Zone and Gurage Zone of the southern Ethiopia region. DR-TB cases were confirmed by drug-susceptibility testing who were on treatment for DR-TB at Yirgalem and Butajira Hospitals. Controls were smear-positive pulmonary tuberculosis (TB) patients who were taking first-line anti-TB medications and sputum smear-negative at the 5(th) month of commencing TB treatment. Data were entered and cleaned using EPI-Info version 7 software and analyzed using SPSS version 22 statistical software. RESULTS: A total of 84 cases and 243 controls participated in the study. About 59% (49 cases) and 55% (132 controls) were male. The median (interquartile range) age was 28 (21–37) years for cases and 27 (25–33) years for controls. Living in a one-roomed house (adjusted odds ratio [AOR]: 6.8, 95% CI: 1.8–25.8), history of contact with DR-TB cases (AOR: 6.8, 95% CI: 1.8–25.3), treatment failure TB cases (AOR: 4.2, 95% CI: 1.1–15.5) and relapsed TB cases (AOR: 4.8, 95% CI: 1.3–18.1) were independent factors associated with DR-TB. CONCLUSION: Providing standardized first-line regimen for new case and retreatment TB cases and practicing basic TB-infection control measures could help to minimize the spread of DR-TB.
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spelling pubmed-73059432020-06-29 Determinants of Drug-Resistant Tuberculosis in Southern Ethiopia: A Case–Control Study Biru, Daniel Woldesemayat, Endrias Markos Infect Drug Resist Original Research BACKGROUND: In most developing countries, including in Ethiopia, the magnitude and risk factors of drug-resistant tuberculosis (DR-TB) are expected to be high. However, this is not well reported because of lack of laboratory facilities, poor surveillance system and limited reporting. The aim of this study was to determine the risk factors of DR-TB among TB patients in southern Ethiopia. PATIENTS AND METHODS: Facility-based case–control study was conducted from November 2016 to January 2017 in Sidama Zone and Gurage Zone of the southern Ethiopia region. DR-TB cases were confirmed by drug-susceptibility testing who were on treatment for DR-TB at Yirgalem and Butajira Hospitals. Controls were smear-positive pulmonary tuberculosis (TB) patients who were taking first-line anti-TB medications and sputum smear-negative at the 5(th) month of commencing TB treatment. Data were entered and cleaned using EPI-Info version 7 software and analyzed using SPSS version 22 statistical software. RESULTS: A total of 84 cases and 243 controls participated in the study. About 59% (49 cases) and 55% (132 controls) were male. The median (interquartile range) age was 28 (21–37) years for cases and 27 (25–33) years for controls. Living in a one-roomed house (adjusted odds ratio [AOR]: 6.8, 95% CI: 1.8–25.8), history of contact with DR-TB cases (AOR: 6.8, 95% CI: 1.8–25.3), treatment failure TB cases (AOR: 4.2, 95% CI: 1.1–15.5) and relapsed TB cases (AOR: 4.8, 95% CI: 1.3–18.1) were independent factors associated with DR-TB. CONCLUSION: Providing standardized first-line regimen for new case and retreatment TB cases and practicing basic TB-infection control measures could help to minimize the spread of DR-TB. Dove 2020-06-16 /pmc/articles/PMC7305943/ /pubmed/32606831 http://dx.doi.org/10.2147/IDR.S256536 Text en © 2020 Biru and Woldesemayat. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Biru, Daniel
Woldesemayat, Endrias Markos
Determinants of Drug-Resistant Tuberculosis in Southern Ethiopia: A Case–Control Study
title Determinants of Drug-Resistant Tuberculosis in Southern Ethiopia: A Case–Control Study
title_full Determinants of Drug-Resistant Tuberculosis in Southern Ethiopia: A Case–Control Study
title_fullStr Determinants of Drug-Resistant Tuberculosis in Southern Ethiopia: A Case–Control Study
title_full_unstemmed Determinants of Drug-Resistant Tuberculosis in Southern Ethiopia: A Case–Control Study
title_short Determinants of Drug-Resistant Tuberculosis in Southern Ethiopia: A Case–Control Study
title_sort determinants of drug-resistant tuberculosis in southern ethiopia: a case–control study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305943/
https://www.ncbi.nlm.nih.gov/pubmed/32606831
http://dx.doi.org/10.2147/IDR.S256536
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