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CRISPR Screen in Regulatory T Cells Reveals Modulators of Foxp3

Regulatory T cells (Tregs) are required to control immune responses and maintain homeostasis, but are a significant barrier to anti-tumor immunity(1). Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of pro-inflammatory properties(2), can p...

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Detalles Bibliográficos
Autores principales:	Cortez, Jessica T., Montauti, Elena, Shifrut, Eric, Gatchalian, Jovylyn, Zhang, Yusi, Shaked, Oren, Xu, Yuanming, Roth, Theodore L., Simeonov, Dimitre R., Zhang, Yana, Chen, Siqi, Li, Zhongmei, Woo, Jonathan M., Ho, Josephine, Vogel, Ian A., Prator, Grace Y., Zhang, Bin, Lee, Youjin, Sun, Zhaolin, Ifergan, Igal, Van Gool, Frédéric, Hargreaves, Diana C., Bluestone, Jeffrey A., Marson, Alexander, Fang, Deyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305989/ https://www.ncbi.nlm.nih.gov/pubmed/32499641 http://dx.doi.org/10.1038/s41586-020-2246-4

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