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Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials

Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate the neurotransmitter systems involved in the anticipation of reward value and probability. We hypothesized that dopaminergic and noradrenergic antagonism...

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Autores principales: Schutte, Iris, Deschamps, Peter K. H., van Harten, Peter N., Kenemans, J. Leon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306042/
https://www.ncbi.nlm.nih.gov/pubmed/32313980
http://dx.doi.org/10.1007/s00213-020-05515-x
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author Schutte, Iris
Deschamps, Peter K. H.
van Harten, Peter N.
Kenemans, J. Leon
author_facet Schutte, Iris
Deschamps, Peter K. H.
van Harten, Peter N.
Kenemans, J. Leon
author_sort Schutte, Iris
collection PubMed
description Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate the neurotransmitter systems involved in the anticipation of reward value and probability. We hypothesized that dopaminergic and noradrenergic antagonism would affect anticipation of reward value and probability, respectively. Twenty-three healthy participants were included in a haloperidol (2 mg) × clonidine (0.150 mg) × placebo cross-over design and subjected to a Go/NoGo experimental task during which cues signaled the probability of subsequent target appearance. Reward value (amount of money that could be won for correct and fast responding to the target) as well as probability of target appearance was orthogonally manipulated across four task blocks. Cue-elicited EEG event-related potentials were recorded to assess anticipation of value and probability, respectively. The processing of reward value was affected by dopaminergic antagonism (haloperidol), as evidenced by reduction of the reward-related positivity and P300 to reward cues. This reduction was specifically significant for subjects with high baseline dopamine levels for the P300 and most pronounced for these subjects for the reward-related positivity. In contrast, the processing of reward probability was affected by noradrenergic antagonism (clonidine). In addition, both drugs reduced overall performance (omission rate, response speed variability). We conclude that at least anticipation of reward value and probability, respectively, is specifically affected by dopaminergic versus noradrenergic antagonism. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00213-020-05515-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-73060422020-06-22 Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials Schutte, Iris Deschamps, Peter K. H. van Harten, Peter N. Kenemans, J. Leon Psychopharmacology (Berl) Original Investigation Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate the neurotransmitter systems involved in the anticipation of reward value and probability. We hypothesized that dopaminergic and noradrenergic antagonism would affect anticipation of reward value and probability, respectively. Twenty-three healthy participants were included in a haloperidol (2 mg) × clonidine (0.150 mg) × placebo cross-over design and subjected to a Go/NoGo experimental task during which cues signaled the probability of subsequent target appearance. Reward value (amount of money that could be won for correct and fast responding to the target) as well as probability of target appearance was orthogonally manipulated across four task blocks. Cue-elicited EEG event-related potentials were recorded to assess anticipation of value and probability, respectively. The processing of reward value was affected by dopaminergic antagonism (haloperidol), as evidenced by reduction of the reward-related positivity and P300 to reward cues. This reduction was specifically significant for subjects with high baseline dopamine levels for the P300 and most pronounced for these subjects for the reward-related positivity. In contrast, the processing of reward probability was affected by noradrenergic antagonism (clonidine). In addition, both drugs reduced overall performance (omission rate, response speed variability). We conclude that at least anticipation of reward value and probability, respectively, is specifically affected by dopaminergic versus noradrenergic antagonism. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00213-020-05515-x) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-04-20 2020 /pmc/articles/PMC7306042/ /pubmed/32313980 http://dx.doi.org/10.1007/s00213-020-05515-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Investigation
Schutte, Iris
Deschamps, Peter K. H.
van Harten, Peter N.
Kenemans, J. Leon
Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials
title Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials
title_full Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials
title_fullStr Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials
title_full_unstemmed Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials
title_short Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials
title_sort dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306042/
https://www.ncbi.nlm.nih.gov/pubmed/32313980
http://dx.doi.org/10.1007/s00213-020-05515-x
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