Inhibition of oxygen-sensing prolyl hydroxylases increases lipid accumulation in human primary tubular epithelial cells without inducing ER stress

The role of the hypoxia-inducible transcription factor (HIF) pathway in renal lipid metabolism is largely unknown. As HIF stabilizing prolyl hydroxylase (PHD) inhibitors are currently investigated in clinical trials for the treatment of renal anemia, we studied the effects of genetic deletion and ph...

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Detalles Bibliográficos
Autores principales: Schley, Gunnar, Grampp, Steffen, Goppelt-Struebe, Margarete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306052/
https://www.ncbi.nlm.nih.gov/pubmed/32189058
http://dx.doi.org/10.1007/s00441-020-03186-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306052/
https://www.ncbi.nlm.nih.gov/pubmed/32189058
http://dx.doi.org/10.1007/s00441-020-03186-w

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