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Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications

Fibrosis accompanies most common pathophysiological features of diabetes complications in different organs. It is characterized by an excessive accumulation of extracellular matrix (ECM) components, the response to which contributes to inevitable organ injury. The extracellular protein thrombospondi...

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Detalles Bibliográficos
Autores principales: Xu, Linhao, Zhang, Yong, Chen, Jian, Xu, Yizhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306092/
https://www.ncbi.nlm.nih.gov/pubmed/32626782
http://dx.doi.org/10.1155/2020/8043135
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author Xu, Linhao
Zhang, Yong
Chen, Jian
Xu, Yizhou
author_facet Xu, Linhao
Zhang, Yong
Chen, Jian
Xu, Yizhou
author_sort Xu, Linhao
collection PubMed
description Fibrosis accompanies most common pathophysiological features of diabetes complications in different organs. It is characterized by an excessive accumulation of extracellular matrix (ECM) components, the response to which contributes to inevitable organ injury. The extracellular protein thrombospondin-1 (TSP-1), a kind of extracellular glycoprotein, is upregulated by the increased activity of some transcription factors and results in fibrosis by activating multiple pathways in diabetes. The results of studies from our team and other colleagues indicate that TSP-1 is associated with the pathological process leading to diabetic complications and is considered to be the most important factor in fibrosis. This review summarizes the molecular mechanism of increased TSP-1 induced by hyperglycemia and the role of TSP-1 in fibrosis during the development of diabetes complications.
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spelling pubmed-73060922020-07-02 Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications Xu, Linhao Zhang, Yong Chen, Jian Xu, Yizhou J Diabetes Res Review Article Fibrosis accompanies most common pathophysiological features of diabetes complications in different organs. It is characterized by an excessive accumulation of extracellular matrix (ECM) components, the response to which contributes to inevitable organ injury. The extracellular protein thrombospondin-1 (TSP-1), a kind of extracellular glycoprotein, is upregulated by the increased activity of some transcription factors and results in fibrosis by activating multiple pathways in diabetes. The results of studies from our team and other colleagues indicate that TSP-1 is associated with the pathological process leading to diabetic complications and is considered to be the most important factor in fibrosis. This review summarizes the molecular mechanism of increased TSP-1 induced by hyperglycemia and the role of TSP-1 in fibrosis during the development of diabetes complications. Hindawi 2020-06-11 /pmc/articles/PMC7306092/ /pubmed/32626782 http://dx.doi.org/10.1155/2020/8043135 Text en Copyright © 2020 Linhao Xu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Linhao
Zhang, Yong
Chen, Jian
Xu, Yizhou
Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications
title Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications
title_full Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications
title_fullStr Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications
title_full_unstemmed Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications
title_short Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications
title_sort thrombospondin-1: a key protein that induces fibrosis in diabetic complications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306092/
https://www.ncbi.nlm.nih.gov/pubmed/32626782
http://dx.doi.org/10.1155/2020/8043135
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AT xuyizhou thrombospondin1akeyproteinthatinducesfibrosisindiabeticcomplications