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Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus
A subgroup of COVID-19 patients develop very severe disease with requirement for ICU treatment, ventilation, and ECMO therapy. Laboratory tests indicate that the immune and clotting system show marked alterations with hyper-activation, hyper-inflammation, cytokine storm development. Furthermore, org...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Infection Association. Published by Elsevier Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306198/ https://www.ncbi.nlm.nih.gov/pubmed/32579986 http://dx.doi.org/10.1016/j.jinf.2020.06.039 |
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author | Skevaki, Chrysanthi Fragkou, Paraskevi C. Cheng, Chongsheng Xie, Min Renz, Harald |
author_facet | Skevaki, Chrysanthi Fragkou, Paraskevi C. Cheng, Chongsheng Xie, Min Renz, Harald |
author_sort | Skevaki, Chrysanthi |
collection | PubMed |
description | A subgroup of COVID-19 patients develop very severe disease with requirement for ICU treatment, ventilation, and ECMO therapy. Laboratory tests indicate that the immune and clotting system show marked alterations with hyper-activation, hyper-inflammation, cytokine storm development. Furthermore, organ-specific biomarkers demonstrate the involvement of cardiac muscle, kidney, and liver dysfunction in many patients. In this article the use of laboratory biomarkers is discussed with regard to their use for diagnosis, disease progression, and risk assessment. |
format | Online Article Text |
id | pubmed-7306198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The British Infection Association. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73061982020-06-22 Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus Skevaki, Chrysanthi Fragkou, Paraskevi C. Cheng, Chongsheng Xie, Min Renz, Harald J Infect Review A subgroup of COVID-19 patients develop very severe disease with requirement for ICU treatment, ventilation, and ECMO therapy. Laboratory tests indicate that the immune and clotting system show marked alterations with hyper-activation, hyper-inflammation, cytokine storm development. Furthermore, organ-specific biomarkers demonstrate the involvement of cardiac muscle, kidney, and liver dysfunction in many patients. In this article the use of laboratory biomarkers is discussed with regard to their use for diagnosis, disease progression, and risk assessment. The British Infection Association. Published by Elsevier Ltd. 2020-08 2020-06-21 /pmc/articles/PMC7306198/ /pubmed/32579986 http://dx.doi.org/10.1016/j.jinf.2020.06.039 Text en © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Skevaki, Chrysanthi Fragkou, Paraskevi C. Cheng, Chongsheng Xie, Min Renz, Harald Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus |
title | Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus |
title_full | Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus |
title_fullStr | Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus |
title_full_unstemmed | Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus |
title_short | Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus |
title_sort | laboratory characteristics of patients infected with the novel sars-cov-2 virus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306198/ https://www.ncbi.nlm.nih.gov/pubmed/32579986 http://dx.doi.org/10.1016/j.jinf.2020.06.039 |
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