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A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea
This retrospective study aimed to explore the benefits and safety of probiotics (live combined Bacillus subtilis and Enterococcus faecium granules with multivitamines) for the treatment of children with antibiotic-associated diarrhea (AAD). A total of 72 children with AAD were analyzed in this study...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306351/ https://www.ncbi.nlm.nih.gov/pubmed/32502043 http://dx.doi.org/10.1097/MD.0000000000020631 |
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author | Rui, Xue Ma, Shu-xia |
author_facet | Rui, Xue Ma, Shu-xia |
author_sort | Rui, Xue |
collection | PubMed |
description | This retrospective study aimed to explore the benefits and safety of probiotics (live combined Bacillus subtilis and Enterococcus faecium granules with multivitamines) for the treatment of children with antibiotic-associated diarrhea (AAD). A total of 72 children with AAD were analyzed in this study. Of these, 36 children received routine treatment plus probiotics, and were assigned to a treatment group. The other 36 children underwent routine treatment alone, and were assigned to a control group. Patients in both groups were treated for a total of 7 days. The efficacy and safety were evaluated by duration of diarrhea (days), number of dressings needed daily, abdominal pain intensity, stool consistency (as assessed by Bristol Stool Scale (BSS)), and any adverse events. After treatment, probiotics showed encouraging benefits in decreasing duration of diarrhea (days) (P < .01), number of dressings needed every day (P < .01), abdominal pain intensity (P < .01), and stool consistency (BSS (3–5), P < .01; BSS (6–7), P < .01). In addition, no adverse events were documented in this study. The findings of this study demonstrated that probiotics may provide promising benefit for children with AAD. Further studies are still needed to warrant theses findings. |
format | Online Article Text |
id | pubmed-7306351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-73063512020-07-08 A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea Rui, Xue Ma, Shu-xia Medicine (Baltimore) 3800 This retrospective study aimed to explore the benefits and safety of probiotics (live combined Bacillus subtilis and Enterococcus faecium granules with multivitamines) for the treatment of children with antibiotic-associated diarrhea (AAD). A total of 72 children with AAD were analyzed in this study. Of these, 36 children received routine treatment plus probiotics, and were assigned to a treatment group. The other 36 children underwent routine treatment alone, and were assigned to a control group. Patients in both groups were treated for a total of 7 days. The efficacy and safety were evaluated by duration of diarrhea (days), number of dressings needed daily, abdominal pain intensity, stool consistency (as assessed by Bristol Stool Scale (BSS)), and any adverse events. After treatment, probiotics showed encouraging benefits in decreasing duration of diarrhea (days) (P < .01), number of dressings needed every day (P < .01), abdominal pain intensity (P < .01), and stool consistency (BSS (3–5), P < .01; BSS (6–7), P < .01). In addition, no adverse events were documented in this study. The findings of this study demonstrated that probiotics may provide promising benefit for children with AAD. Further studies are still needed to warrant theses findings. Wolters Kluwer Health 2020-06-05 /pmc/articles/PMC7306351/ /pubmed/32502043 http://dx.doi.org/10.1097/MD.0000000000020631 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 3800 Rui, Xue Ma, Shu-xia A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea |
title | A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea |
title_full | A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea |
title_fullStr | A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea |
title_full_unstemmed | A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea |
title_short | A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea |
title_sort | retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea |
topic | 3800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306351/ https://www.ncbi.nlm.nih.gov/pubmed/32502043 http://dx.doi.org/10.1097/MD.0000000000020631 |
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