Cargando…

Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with an overall 5-year survival rate of 9.3%, and this malignancy is expected to become the second leading cause of cancer-related death by 2030. Gemcitabine resistance develops within weeks of PDAC patient’s chemo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Ya-Hui, Chen, Yi-Chun, Lin, Chi-Chen, Hsieh, Yao-Peng, Hsu, Chien-Sheng, Hsieh, Ming-Chia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306478/ https://www.ncbi.nlm.nih.gov/pubmed/32606957 http://dx.doi.org/10.2147/CMAR.S247876

Ejemplares similares

AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2
por: Fahy, B N, et al.
Publicado: (2003)

Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells
por: DUONG, HONG-QUAN, et al.
Publicado: (2014)

Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells
por: DUONG, HONG-QUAN, et al.
Publicado: (2012)

Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines
por: Park, S.H., et al.
Publicado: (2014)

Effects of a Non Thermal Plasma Treatment Alone or in Combination with Gemcitabine in a MIA PaCa2-luc Orthotopic Pancreatic Carcinoma Model
por: Brullé, Laura, et al.
Publicado: (2012)

Indirect antiproliferative effect of the somatostatin analog octreotide on MIA PaCa-2 human pancreatic carcinoma in nude mice.
por: Weckbecker, G., et al.
Publicado: (1997)

Efficient Selection of Enhancers and Promoters from MIA PaCa-2 Pancreatic Cancer Cells by ChIP-lentiMPRA
por: Kashkin, Kirill Nikitich, et al.
Publicado: (2022)

MIA PaCa-2 and PANC-1 – pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors
por: Gradiz, Rui, et al.
Publicado: (2016)

Role of Intracellular and Extracellular Annexin A1 in MIA PaCa-2 Spheroids Formation and Drug Sensitivity
por: Novizio, Nunzia, et al.
Publicado: (2022)

Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro.
por: Ohmura, E., et al.
Publicado: (1993)

PW06 Triggered Fas-FADD to Induce Apoptotic Cell Death In Human Pancreatic Carcinoma MIA PaCa-2 Cells through the Activation of the Caspase-Mediated Pathway
por: Huang, Yi-Ping, et al.
Publicado: (2023)

Ganglioside GM2, highly expressed in the MIA PaCa-2 pancreatic ductal adenocarcinoma cell line, is correlated with growth, invasion, and advanced stage
por: Sasaki, Norihiko, et al.
Publicado: (2019)

Machine Learning Approach to Raman Spectrum Analysis of MIA PaCa-2 Pancreatic Cancer Tumor Repopulating Cells for Classification and Feature Analysis
por: Mandrell, Christopher T., et al.
Publicado: (2020)

Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma
por: Mandys, Václav, et al.
Publicado: (2023)

Apoptosis induction and proliferation inhibition by silibinin encapsulated in nanoparticles in MIA PaCa-2 cancer cells and deregulation of some miRNAs
por: Khakinezhad Tehrani, Fatemeh, et al.
Publicado: (2020)

Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990
por: Milanović, Dušan, et al.
Publicado: (2013)

Notch signaling via regulation of RB and p-AKT but not PIK3CG contributes to MIA PaCa-2 cell growth and migration to affect pancreatic carcinogenesis
por: Zhang, Shubing, et al.
Publicado: (2018)

GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals
por: Abrams, Stephen L., et al.
Publicado: (2021)

Apoptotic Effect of Gallic Acid via Regulation of p-p38 and ER Stress in PANC-1 and MIA PaCa-2 Cells Pancreatic Cancer Cells
por: Kim, Jeong Woo, et al.
Publicado: (2023)

Differentially Expressed microRNAs in MIA PaCa-2 and PANC-1 Pancreas Ductal Adenocarcinoma Cell Lines are Involved in Cancer Stem Cell Regulation
por: Shen, Ye, et al.
Publicado: (2019)

Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System
por: Pessolano, Emanuela, et al.
Publicado: (2018)

Multidrug resistance protein 5 affects cell proliferation, migration and gemcitabine sensitivity in pancreatic cancer MIA Paca‑2 and PANC‑1 cells
por: He, Ji, et al.
Publicado: (2023)

The Effect of HIF-1α siRNA on Growth and Chemosensitivity of Mia-paca Cell Line
por: Yang, Lily, et al.
Publicado: (2008)

Inhibitory effect of (−)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancer MiaPaca-2 cell growth
por: Bimonte, Sabrina, et al.
Publicado: (2015)

A Potent HDAC Inhibitor, 1-Alaninechlamydocin, from a Tolypocladium sp. Induces G2/M Cell Cycle Arrest and Apoptosis in MIA PaCa-2 Cells
por: Du, Lin, et al.
Publicado: (2014)

Nano-SAR Modeling for Predicting the Cytotoxicity of Metal Oxide Nanoparticles to PaCa2
por: Shi, Haihua, et al.
Publicado: (2021)

Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins
por: Rimpelová, Silvie, et al.
Publicado: (2021)

Effects and mechanism of siomycin A on the growth and apoptosis of MiaPaCa-2 cancer cells
por: Wang, Bin, et al.
Publicado: (2019)

TNFα and TGFβ-1 synergistically increase the cancer stem cell properties of MiaPaCa-2 cells
por: Kali, Aikyn, et al.
Publicado: (2017)

Placentation in the paca (Agouti paca L)
por: Bonatelli, Marina, et al.
Publicado: (2005)

Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death
por: Nakamura, M, et al.
Publicado: (2016)

A synergic approach to enhance long-term culture and manipulation of MiaPaCa-2 pancreatic cancer spheroids
por: Cavo, Marta, et al.
Publicado: (2020)

Danmark hægtet på internationalt mia-projekt
por: Stokholm, P
Publicado: (1995)

Vocal complexity and sociality in spotted paca (Cuniculus paca)
por: Lima, Stella G. C., et al.
Publicado: (2018)

Paca : cría y manejo.

Paca : cría y manejo.

Notch signaling molecule is involved in the invasion of MiaPaCa2 cells induced by CoCl(2) via regulating epithelial-mesenchymal transition
por: Chen, Ding-Wei, et al.
Publicado: (2018)

Gemcitabine and XCT790, an ERRα inverse agonist, display a synergistic anticancer effect in pancreatic cancer
por: Liu, Shi-lei, et al.
Publicado: (2022)

Exosomal lipids induce human pancreatic tumoral MiaPaCa-2 cells resistance through the CXCR4-SDF-1α signaling axis
por: Beloribi-Djefaflia, Sadia, et al.
Publicado: (2014)

Heterologous microsatellite primers are informative for paca (Cuniculus paca), a large rodent with economic and ecological importance
por: Gallardo, Franco F. Roldán, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mjkt4sakvf785uf74o84tqbqg5