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Decoding the global outbreak of COVID-19: the nature is behind the scene

The sudden emergence of SARS-CoV-2 causing the global pandemic is a major public health concern. Though the virus is considered as a novel entity, it is not a completely new member. It is just a new version of previously emerged human SARS corona virus. The rapid evolving nature by changing host bod...

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Detalles Bibliográficos
Autores principales: Das, Piyanki, Choudhuri, Tathagata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306562/
https://www.ncbi.nlm.nih.gov/pubmed/32656307
http://dx.doi.org/10.1007/s13337-020-00605-y
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author Das, Piyanki
Choudhuri, Tathagata
author_facet Das, Piyanki
Choudhuri, Tathagata
author_sort Das, Piyanki
collection PubMed
description The sudden emergence of SARS-CoV-2 causing the global pandemic is a major public health concern. Though the virus is considered as a novel entity, it is not a completely new member. It is just a new version of previously emerged human SARS corona virus. The rapid evolving nature by changing host body environment and extreme environmental stability, collectively makes SARS-CoV-2 into an extremely virulent genetic variant. The evolution of the virus has been occurred by the continuous process of molecular genetic manipulation, through mutation, deletion and genetic recombinationevents. Different host body environment acts as the supportive system for the pathogen which creates extreme selective pressure. By the process of genetic evolution the pathogen developes new characters. Then the new version of the virus has been naturally selected by susceptible human host and adapt itself inside the host body causing deadly effect. Moreover, extreme environmental stability helps in the process of viral survival outside the host and its transmission. Thus both the host body or internal environment and the external environment performs equally as a source, responsible for shaping the genetic evolution of the SARS-CoV-2 towards theCOVID-19 disease fitness in nature in a pandemic form.
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spelling pubmed-73065622020-06-22 Decoding the global outbreak of COVID-19: the nature is behind the scene Das, Piyanki Choudhuri, Tathagata Virusdisease Review Article The sudden emergence of SARS-CoV-2 causing the global pandemic is a major public health concern. Though the virus is considered as a novel entity, it is not a completely new member. It is just a new version of previously emerged human SARS corona virus. The rapid evolving nature by changing host body environment and extreme environmental stability, collectively makes SARS-CoV-2 into an extremely virulent genetic variant. The evolution of the virus has been occurred by the continuous process of molecular genetic manipulation, through mutation, deletion and genetic recombinationevents. Different host body environment acts as the supportive system for the pathogen which creates extreme selective pressure. By the process of genetic evolution the pathogen developes new characters. Then the new version of the virus has been naturally selected by susceptible human host and adapt itself inside the host body causing deadly effect. Moreover, extreme environmental stability helps in the process of viral survival outside the host and its transmission. Thus both the host body or internal environment and the external environment performs equally as a source, responsible for shaping the genetic evolution of the SARS-CoV-2 towards theCOVID-19 disease fitness in nature in a pandemic form. Springer India 2020-06-22 2020-06 /pmc/articles/PMC7306562/ /pubmed/32656307 http://dx.doi.org/10.1007/s13337-020-00605-y Text en © Indian Virological Society 2020
spellingShingle Review Article
Das, Piyanki
Choudhuri, Tathagata
Decoding the global outbreak of COVID-19: the nature is behind the scene
title Decoding the global outbreak of COVID-19: the nature is behind the scene
title_full Decoding the global outbreak of COVID-19: the nature is behind the scene
title_fullStr Decoding the global outbreak of COVID-19: the nature is behind the scene
title_full_unstemmed Decoding the global outbreak of COVID-19: the nature is behind the scene
title_short Decoding the global outbreak of COVID-19: the nature is behind the scene
title_sort decoding the global outbreak of covid-19: the nature is behind the scene
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306562/
https://www.ncbi.nlm.nih.gov/pubmed/32656307
http://dx.doi.org/10.1007/s13337-020-00605-y
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