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Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection

INTRODUCTION: Currently, gastroesophageal reflux disease (GERD) is one of the most ubiquitous problems in clinical practice. An antacid-alginate combination (under the trade name Gaviscon) is a natural-based product that effectively suppresses GERD. This product acts via the formation of viscous gel...

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Autores principales: Moayedi, Saeed, Yadegar, Abbas, Balalaie, Saeed, Yarmohammadi, Mahdiyeh, Zali, Mohammad Reza, Suzuki, Hidekazu, Fricker, Gert, Haririan, Ismaeil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306573/
https://www.ncbi.nlm.nih.gov/pubmed/32606607
http://dx.doi.org/10.2147/DDDT.S255611
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author Moayedi, Saeed
Yadegar, Abbas
Balalaie, Saeed
Yarmohammadi, Mahdiyeh
Zali, Mohammad Reza
Suzuki, Hidekazu
Fricker, Gert
Haririan, Ismaeil
author_facet Moayedi, Saeed
Yadegar, Abbas
Balalaie, Saeed
Yarmohammadi, Mahdiyeh
Zali, Mohammad Reza
Suzuki, Hidekazu
Fricker, Gert
Haririan, Ismaeil
author_sort Moayedi, Saeed
collection PubMed
description INTRODUCTION: Currently, gastroesophageal reflux disease (GERD) is one of the most ubiquitous problems in clinical practice. An antacid-alginate combination (under the trade name Gaviscon) is a natural-based product that effectively suppresses GERD. This product acts via the formation of viscous gel that floats on the top of the gastric content. On the other hand, efficient management of Helicobacter pylori infection with minimal side effects is an important goal for gastroenterologists. Furthermore, some H. pylori-positive patients suffer from GERD. METHODS: Here, we present the results of investigations on alginate conjugated to sugar codes in order to find initial clues regarding the potential ability of this conjugate in the simultaneous prophylaxis of GERD and H. pylori infection in an in vitro assay. RESULTS: It is noteworthy that our results reveal that sugar codes conjugated alginate considerably decrease (approximately 74%) the adhesion of H. pylori to gastric epithelial cells in vitro. Moreover, surprisingly after conjugation of sugar codes, alginate can maintain its ability to create gel. Our results demonstrate that alginate conjugated to sugar codes is not cytotoxic. CONCLUSION: The preparation of these conjugates can be regarded as the first step to establish a new roadmap for the simultaneous prevention of GERD and H. pylori infection in future studies on in vivo models.
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spelling pubmed-73065732020-06-29 Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection Moayedi, Saeed Yadegar, Abbas Balalaie, Saeed Yarmohammadi, Mahdiyeh Zali, Mohammad Reza Suzuki, Hidekazu Fricker, Gert Haririan, Ismaeil Drug Des Devel Ther Original Research INTRODUCTION: Currently, gastroesophageal reflux disease (GERD) is one of the most ubiquitous problems in clinical practice. An antacid-alginate combination (under the trade name Gaviscon) is a natural-based product that effectively suppresses GERD. This product acts via the formation of viscous gel that floats on the top of the gastric content. On the other hand, efficient management of Helicobacter pylori infection with minimal side effects is an important goal for gastroenterologists. Furthermore, some H. pylori-positive patients suffer from GERD. METHODS: Here, we present the results of investigations on alginate conjugated to sugar codes in order to find initial clues regarding the potential ability of this conjugate in the simultaneous prophylaxis of GERD and H. pylori infection in an in vitro assay. RESULTS: It is noteworthy that our results reveal that sugar codes conjugated alginate considerably decrease (approximately 74%) the adhesion of H. pylori to gastric epithelial cells in vitro. Moreover, surprisingly after conjugation of sugar codes, alginate can maintain its ability to create gel. Our results demonstrate that alginate conjugated to sugar codes is not cytotoxic. CONCLUSION: The preparation of these conjugates can be regarded as the first step to establish a new roadmap for the simultaneous prevention of GERD and H. pylori infection in future studies on in vivo models. Dove 2020-06-17 /pmc/articles/PMC7306573/ /pubmed/32606607 http://dx.doi.org/10.2147/DDDT.S255611 Text en © 2020 Moayedi et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Moayedi, Saeed
Yadegar, Abbas
Balalaie, Saeed
Yarmohammadi, Mahdiyeh
Zali, Mohammad Reza
Suzuki, Hidekazu
Fricker, Gert
Haririan, Ismaeil
Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection
title Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection
title_full Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection
title_fullStr Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection
title_full_unstemmed Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection
title_short Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection
title_sort sugar codes conjugated alginate: an innovative platform to make a strategic breakthrough in simultaneous prophylaxis of gerd and helicobacter pylori infection
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306573/
https://www.ncbi.nlm.nih.gov/pubmed/32606607
http://dx.doi.org/10.2147/DDDT.S255611
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