Cargando…
TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis
Precisely controlling the activation of transcription factors is crucial for physiology. After a transcription factor is activated and carries out its transcriptional activity, it also needs to be properly deactivated. Here, we report a deactivation mechanism of HIF-1 and several other oncogenic tra...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306777/ https://www.ncbi.nlm.nih.gov/pubmed/32482854 http://dx.doi.org/10.1073/pnas.1921815117 |