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Capn3 depletion causes Chk1 and Wee1 accumulation and disrupts synchronization of cell cycle reentry during liver regeneration after partial hepatectomy

Recovery of liver mass to a healthy liver donor by compensatory regeneration after partial hepatectomy (PH) is a prerequisite for liver transplantation. Synchronized cell cycle reentry of the existing hepatocytes after PH is seemingly a hallmark of liver compensatory regeneration. Although the molec...

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Detalles Bibliográficos
Autores principales: Chen, Feng, Huang, Delai, Shi, Hui, Gao, Ce, Wang, Yingchun, Peng, Jinrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306836/
https://www.ncbi.nlm.nih.gov/pubmed/32588143
http://dx.doi.org/10.1186/s13619-020-00049-1