Cargando…

Picornavirus Identified in Alzheimer’s Disease Brains: A Pathogenic Path?

We investigated formalin-fixed postmortem brain tissue from the hippocampus region of 18 AD cases and 11 age-matched controls using a polyclonal antibody against Ljungan virus (LV) capsid protein 1. Evidence of a LV antigen was found in all AD cases but in none of the control specimens (p < 0.000...

Descripción completa

Detalles Bibliográficos
Autores principales: Niklasson, Bo, Lindquist, Lars, Klitz, William, Englund, Elisabet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306919/
https://www.ncbi.nlm.nih.gov/pubmed/32587947
http://dx.doi.org/10.3233/ADR-200174
_version_ 1783548740653547520
author Niklasson, Bo
Lindquist, Lars
Klitz, William
Englund, Elisabet
author_facet Niklasson, Bo
Lindquist, Lars
Klitz, William
Englund, Elisabet
author_sort Niklasson, Bo
collection PubMed
description We investigated formalin-fixed postmortem brain tissue from the hippocampus region of 18 AD cases and 11 age-matched controls using a polyclonal antibody against Ljungan virus (LV) capsid protein 1. Evidence of a LV antigen was found in all AD cases but in none of the control specimens (p < 0.0001). The antibodies reacted with neurons and astrocytes and also showed distinct positive reaction in the amyloid/neuritic plaques. The possible role of an incompletely characterized picornavirus as the etiologic agent in AD open up the possibility of treatment with antiviral therapy directed against picornaviruses. The positive result of such treatment in a small number of patients is presented separately back to back to this report.
format Online
Article
Text
id pubmed-7306919
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher IOS Press
record_format MEDLINE/PubMed
spelling pubmed-73069192020-06-24 Picornavirus Identified in Alzheimer’s Disease Brains: A Pathogenic Path? Niklasson, Bo Lindquist, Lars Klitz, William Englund, Elisabet J Alzheimers Dis Rep Research Report We investigated formalin-fixed postmortem brain tissue from the hippocampus region of 18 AD cases and 11 age-matched controls using a polyclonal antibody against Ljungan virus (LV) capsid protein 1. Evidence of a LV antigen was found in all AD cases but in none of the control specimens (p < 0.0001). The antibodies reacted with neurons and astrocytes and also showed distinct positive reaction in the amyloid/neuritic plaques. The possible role of an incompletely characterized picornavirus as the etiologic agent in AD open up the possibility of treatment with antiviral therapy directed against picornaviruses. The positive result of such treatment in a small number of patients is presented separately back to back to this report. IOS Press 2020-05-20 /pmc/articles/PMC7306919/ /pubmed/32587947 http://dx.doi.org/10.3233/ADR-200174 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Report
Niklasson, Bo
Lindquist, Lars
Klitz, William
Englund, Elisabet
Picornavirus Identified in Alzheimer’s Disease Brains: A Pathogenic Path?
title Picornavirus Identified in Alzheimer’s Disease Brains: A Pathogenic Path?
title_full Picornavirus Identified in Alzheimer’s Disease Brains: A Pathogenic Path?
title_fullStr Picornavirus Identified in Alzheimer’s Disease Brains: A Pathogenic Path?
title_full_unstemmed Picornavirus Identified in Alzheimer’s Disease Brains: A Pathogenic Path?
title_short Picornavirus Identified in Alzheimer’s Disease Brains: A Pathogenic Path?
title_sort picornavirus identified in alzheimer’s disease brains: a pathogenic path?
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306919/
https://www.ncbi.nlm.nih.gov/pubmed/32587947
http://dx.doi.org/10.3233/ADR-200174
work_keys_str_mv AT niklassonbo picornavirusidentifiedinalzheimersdiseasebrainsapathogenicpath
AT lindquistlars picornavirusidentifiedinalzheimersdiseasebrainsapathogenicpath
AT klitzwilliam picornavirusidentifiedinalzheimersdiseasebrainsapathogenicpath
AT picornavirusidentifiedinalzheimersdiseasebrainsapathogenicpath
AT englundelisabet picornavirusidentifiedinalzheimersdiseasebrainsapathogenicpath