Biological sex impacts COVID-19 outcomes

The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male–female differences in COVID-19 cases, hospitalizations, and deaths. W...

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Detalles Bibliográficos
Autores principales: Klein, Sabra L., Dhakal, Santosh, Ursin, Rebecca L., Deshpande, Sharvari, Sandberg, Kathryn, Mauvais-Jarvis, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307725/
https://www.ncbi.nlm.nih.gov/pubmed/32569293
http://dx.doi.org/10.1371/journal.ppat.1008570
Descripción
Sumario:The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male–female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.

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