Biological sex impacts COVID-19 outcomes

The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male–female differences in COVID-19 cases, hospitalizations, and deaths. W...

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Detalles Bibliográficos
Autores principales: Klein, Sabra L., Dhakal, Santosh, Ursin, Rebecca L., Deshpande, Sharvari, Sandberg, Kathryn, Mauvais-Jarvis, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307725/
https://www.ncbi.nlm.nih.gov/pubmed/32569293
http://dx.doi.org/10.1371/journal.ppat.1008570
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author Klein, Sabra L.
Dhakal, Santosh
Ursin, Rebecca L.
Deshpande, Sharvari
Sandberg, Kathryn
Mauvais-Jarvis, Franck
author_facet Klein, Sabra L.
Dhakal, Santosh
Ursin, Rebecca L.
Deshpande, Sharvari
Sandberg, Kathryn
Mauvais-Jarvis, Franck
author_sort Klein, Sabra L.
collection PubMed
description The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male–female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.
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spelling pubmed-73077252020-06-25 Biological sex impacts COVID-19 outcomes Klein, Sabra L. Dhakal, Santosh Ursin, Rebecca L. Deshpande, Sharvari Sandberg, Kathryn Mauvais-Jarvis, Franck PLoS Pathog Opinion The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male–female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19. Public Library of Science 2020-06-22 /pmc/articles/PMC7307725/ /pubmed/32569293 http://dx.doi.org/10.1371/journal.ppat.1008570 Text en © 2020 Klein et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Opinion
Klein, Sabra L.
Dhakal, Santosh
Ursin, Rebecca L.
Deshpande, Sharvari
Sandberg, Kathryn
Mauvais-Jarvis, Franck
Biological sex impacts COVID-19 outcomes
title Biological sex impacts COVID-19 outcomes
title_full Biological sex impacts COVID-19 outcomes
title_fullStr Biological sex impacts COVID-19 outcomes
title_full_unstemmed Biological sex impacts COVID-19 outcomes
title_short Biological sex impacts COVID-19 outcomes
title_sort biological sex impacts covid-19 outcomes
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307725/
https://www.ncbi.nlm.nih.gov/pubmed/32569293
http://dx.doi.org/10.1371/journal.ppat.1008570
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