NCX1 represents an ionic Na(+) sensing mechanism in macrophages

Inflammation and infection can trigger local tissue Na(+) accumulation. This Na(+)-rich environment boosts proinflammatory activation of monocyte/macrophage-like cells (MΦs) and their antimicrobial activity. Enhanced Na(+)-driven MΦ function requires the osmoprotective transcription factor nuclear f...

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Detalles Bibliográficos
Autores principales: Neubert, Patrick, Homann, Arne, Wendelborn, David, Bär, Anna-Lorena, Krampert, Luka, Trum, Maximilian, Schröder, Agnes, Ebner, Stefan, Weichselbaum, Andrea, Schatz, Valentin, Linz, Peter, Veelken, Roland, Schulte-Schrepping, Jonas, Aschenbrenner, Anna C., Quast, Thomas, Kurts, Christian, Geisberger, Sabrina, Kunzelmann, Karl, Hammer, Karin, Binger, Katrina J., Titze, Jens, Müller, Dominik N., Kolanus, Waldemar, Schultze, Joachim L., Wagner, Stefan, Jantsch, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307728/
https://www.ncbi.nlm.nih.gov/pubmed/32569301
http://dx.doi.org/10.1371/journal.pbio.3000722

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