Energy Landscapes Reveal Agonist Control of G Protein-Coupled Receptor Activation via Microswitches

[Image: see text] Agonist binding to G protein-coupled receptors (GPCRs) leads to conformational changes in the transmembrane region that activate cytosolic signaling pathways. Although high-resolution structures of different receptor states are available, atomistic details of allosteric signaling a...

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Detalles Bibliográficos
Autores principales: Fleetwood, Oliver, Matricon, Pierre, Carlsson, Jens, Delemotte, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307880/
https://www.ncbi.nlm.nih.gov/pubmed/31999436
http://dx.doi.org/10.1021/acs.biochem.9b00842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307880/
https://www.ncbi.nlm.nih.gov/pubmed/31999436
http://dx.doi.org/10.1021/acs.biochem.9b00842

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