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Imidazole–Imidazole Hydrogen Bonding in the pH-Sensing Histidine Side Chains of Influenza A M2
[Image: see text] The arrangement of histidine side chains in influenza A M2 tetramer determines their pK(a) values, which define pH-controlled proton conduction critical to the virus lifecycle. Both water-associated and hydrogen-bonded imidazole–imidazolium histidine quaternary structures have been...
Autores principales: | Movellan, Kumar Tekwani, Wegstroth, Melanie, Overkamp, Kerstin, Leonov, Andrei, Becker, Stefan, Andreas, Loren B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307898/ https://www.ncbi.nlm.nih.gov/pubmed/31970979 http://dx.doi.org/10.1021/jacs.9b10984 |
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