Cargando…
Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs): Miniperspective
[Image: see text] The emergence of bacterial resistance against life-saving medicines has forced the scientific community and pharmaceutical industry to take actions in the quest for novel antibacterials. These should not only overcome the existing bacterial resistance but also provide at least inte...
Autores principales: | Kolarič, Anja, Anderluh, Marko, Minovski, Nikola |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307926/ https://www.ncbi.nlm.nih.gov/pubmed/32027491 http://dx.doi.org/10.1021/acs.jmedchem.9b01738 |
Ejemplares similares
-
A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs
por: Kolarič, Anja, et al.
Publicado: (2021) -
The Structural
Features of Novel Bacterial Topoisomerase
Inhibitors That Define Their Activity on Topoisomerase IV
por: Kokot, Maja, et al.
Publicado: (2022) -
Exploring Alternative Pathways to Target Bacterial Type II Topoisomerases Using NBTI Antibacterials: Beyond Halogen-Bonding Interactions
por: Kokot, Maja, et al.
Publicado: (2023) -
Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
por: Kolarič, Anja, et al.
Publicado: (2021) -
Successes and Challenges in
Phenotype-Based Lead Discovery
for Prion Diseases: Miniperspective
por: Ghaemmaghami, Sina, et al.
Publicado: (2014)