Cargando…
QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer
BACKGROUND: Esophagectomy for cancer strongly impairs quality of life. The aim of this trial was to evaluate the effect of the nutritional and respiratory counseling on postoperative quality of life. METHODS: At hospital discharge, patients were randomized into four groups receiving respectively: nu...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307937/ https://www.ncbi.nlm.nih.gov/pubmed/32572611 http://dx.doi.org/10.1007/s00520-020-05573-z |
_version_ | 1783548902567313408 |
---|---|
author | Pinto, Eleonora Nardi, Maria Teresa Marchi, Rita Cavallin, Francesco Alfieri, Rita Saadeh, Luca Cagol, Matteo Baldan, Ilaria Saraceni, Elisabetta Parotto, Matteo Baratto, Fabio Caberlotto, Cristina Vianello, Andrea Castoro, Carlo Scarpa, Marco |
author_facet | Pinto, Eleonora Nardi, Maria Teresa Marchi, Rita Cavallin, Francesco Alfieri, Rita Saadeh, Luca Cagol, Matteo Baldan, Ilaria Saraceni, Elisabetta Parotto, Matteo Baratto, Fabio Caberlotto, Cristina Vianello, Andrea Castoro, Carlo Scarpa, Marco |
author_sort | Pinto, Eleonora |
collection | PubMed |
description | BACKGROUND: Esophagectomy for cancer strongly impairs quality of life. The aim of this trial was to evaluate the effect of the nutritional and respiratory counseling on postoperative quality of life. METHODS: At hospital discharge, patients were randomized into four groups receiving respectively: nutritional and respiratory counseling, nutritional counseling alone, respiratory counseling alone, or standard care. The main endpoint was the impairment in quality of life in the first month after surgery. Linear mixed effect models were estimated to assess mean score differences (MDs) in quality of life scores. RESULTS: Patients receiving nutritional counseling reported less appetite loss (MD − 17.7, 95% CI − 32.2 to −3.3) than those not receiving nutritional counseling at 1 month after surgery. Dyspnea was similar between patients receiving vs. those not receiving respiratory counseling (MD − 3.1, 95% CI − 10.8 to 4.6). Global quality of life was clinically similar between patients receiving vs. those not receiving nutritional counseling over time (MD 0.9, 95% CI − 5.5 to 7.3), as well as in patients receiving vs. those not receiving respiratory counseling over time (MD 0.7, 95% CI − 5.9 to 7.2). CONCLUSIONS: Intensive postoperative care does not affect global quality of life even if nutritional counseling reduced appetite loss. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00520-020-05573-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7307937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-73079372020-06-23 QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer Pinto, Eleonora Nardi, Maria Teresa Marchi, Rita Cavallin, Francesco Alfieri, Rita Saadeh, Luca Cagol, Matteo Baldan, Ilaria Saraceni, Elisabetta Parotto, Matteo Baratto, Fabio Caberlotto, Cristina Vianello, Andrea Castoro, Carlo Scarpa, Marco Support Care Cancer Original Article BACKGROUND: Esophagectomy for cancer strongly impairs quality of life. The aim of this trial was to evaluate the effect of the nutritional and respiratory counseling on postoperative quality of life. METHODS: At hospital discharge, patients were randomized into four groups receiving respectively: nutritional and respiratory counseling, nutritional counseling alone, respiratory counseling alone, or standard care. The main endpoint was the impairment in quality of life in the first month after surgery. Linear mixed effect models were estimated to assess mean score differences (MDs) in quality of life scores. RESULTS: Patients receiving nutritional counseling reported less appetite loss (MD − 17.7, 95% CI − 32.2 to −3.3) than those not receiving nutritional counseling at 1 month after surgery. Dyspnea was similar between patients receiving vs. those not receiving respiratory counseling (MD − 3.1, 95% CI − 10.8 to 4.6). Global quality of life was clinically similar between patients receiving vs. those not receiving nutritional counseling over time (MD 0.9, 95% CI − 5.5 to 7.3), as well as in patients receiving vs. those not receiving respiratory counseling over time (MD 0.7, 95% CI − 5.9 to 7.2). CONCLUSIONS: Intensive postoperative care does not affect global quality of life even if nutritional counseling reduced appetite loss. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00520-020-05573-z) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-06-22 2021 /pmc/articles/PMC7307937/ /pubmed/32572611 http://dx.doi.org/10.1007/s00520-020-05573-z Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Pinto, Eleonora Nardi, Maria Teresa Marchi, Rita Cavallin, Francesco Alfieri, Rita Saadeh, Luca Cagol, Matteo Baldan, Ilaria Saraceni, Elisabetta Parotto, Matteo Baratto, Fabio Caberlotto, Cristina Vianello, Andrea Castoro, Carlo Scarpa, Marco QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer |
title | QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer |
title_full | QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer |
title_fullStr | QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer |
title_full_unstemmed | QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer |
title_short | QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer |
title_sort | qolec2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307937/ https://www.ncbi.nlm.nih.gov/pubmed/32572611 http://dx.doi.org/10.1007/s00520-020-05573-z |
work_keys_str_mv | AT pintoeleonora qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT nardimariateresa qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT marchirita qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT cavallinfrancesco qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT alfieririta qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT saadehluca qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT cagolmatteo qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT baldanilaria qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT saracenielisabetta qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT parottomatteo qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT barattofabio qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT caberlottocristina qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT vianelloandrea qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT castorocarlo qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer AT scarpamarco qolec2arandomizedcontrolledtrialonnutritionalandrespiratorycounselingafteresophagectomyforcancer |