Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions

[Image: see text] In this contribution, we report novel palladium-catalyzed carbonylative cascade approaches to highly functionalized polyheterocyclic structures. The Pd-catalyzed carbonylative process involves the regioselective insertion of one to three CO molecules and the sequential ordered form...

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Autores principales: Pancrazzi, Francesco, Sarti, Nicolò, Mazzeo, Paolo P., Bacchi, Alessia, Carfagna, Carla, Mancuso, Raffaella, Gabriele, Bartolo, Costa, Mirco, Stirling, András, Della Ca’, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307965/
https://www.ncbi.nlm.nih.gov/pubmed/32011899
http://dx.doi.org/10.1021/acs.orglett.0c00171
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author Pancrazzi, Francesco
Sarti, Nicolò
Mazzeo, Paolo P.
Bacchi, Alessia
Carfagna, Carla
Mancuso, Raffaella
Gabriele, Bartolo
Costa, Mirco
Stirling, András
Della Ca’, Nicola
author_facet Pancrazzi, Francesco
Sarti, Nicolò
Mazzeo, Paolo P.
Bacchi, Alessia
Carfagna, Carla
Mancuso, Raffaella
Gabriele, Bartolo
Costa, Mirco
Stirling, András
Della Ca’, Nicola
author_sort Pancrazzi, Francesco
collection PubMed
description [Image: see text] In this contribution, we report novel palladium-catalyzed carbonylative cascade approaches to highly functionalized polyheterocyclic structures. The Pd-catalyzed carbonylative process involves the regioselective insertion of one to three CO molecules and the sequential ordered formation of up to eight new bonds (one C–O, two C–C, five C–N). The exclusive formation of six-membered heterocycles is elucidated by detailed modeling studies.
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spelling pubmed-73079652020-06-23 Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions Pancrazzi, Francesco Sarti, Nicolò Mazzeo, Paolo P. Bacchi, Alessia Carfagna, Carla Mancuso, Raffaella Gabriele, Bartolo Costa, Mirco Stirling, András Della Ca’, Nicola Org Lett [Image: see text] In this contribution, we report novel palladium-catalyzed carbonylative cascade approaches to highly functionalized polyheterocyclic structures. The Pd-catalyzed carbonylative process involves the regioselective insertion of one to three CO molecules and the sequential ordered formation of up to eight new bonds (one C–O, two C–C, five C–N). The exclusive formation of six-membered heterocycles is elucidated by detailed modeling studies. American Chemical Society 2020-02-03 2020-02-21 /pmc/articles/PMC7307965/ /pubmed/32011899 http://dx.doi.org/10.1021/acs.orglett.0c00171 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Pancrazzi, Francesco
Sarti, Nicolò
Mazzeo, Paolo P.
Bacchi, Alessia
Carfagna, Carla
Mancuso, Raffaella
Gabriele, Bartolo
Costa, Mirco
Stirling, András
Della Ca’, Nicola
Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions
title Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions
title_full Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions
title_fullStr Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions
title_full_unstemmed Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions
title_short Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions
title_sort site-selective double and tetracyclization routes to fused polyheterocyclic structures by pd-catalyzed carbonylation reactions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307965/
https://www.ncbi.nlm.nih.gov/pubmed/32011899
http://dx.doi.org/10.1021/acs.orglett.0c00171
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