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LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling
The initiation of puberty is driven by an upsurge in hypothalamic gonadotropin-releasing hormone (GnRH) secretion. In turn, GnRH secretion upsurge depends on the development of a complex GnRH neuroendocrine network during embryonic life. Although delayed puberty (DP) affects up to 2% of the populati...
Autores principales: | Mancini, Alessandra, Howard, Sasha R., Marelli, Federica, Cabrera, Claudia P., Barnes, Michael R., Sternberg, Michael J.E., Leprovots, Morgane, Hadjidemetriou, Irene, Monti, Elena, David, Alessia, Wehkalampi, Karoliina, Oleari, Roberto, Lettieri, Antonella, Vezzoli, Valeria, Vassart, Gilbert, Cariboni, Anna, Bonomi, Marco, Garcia, Marie Isabelle, Guasti, Leonardo, Dunkel, Leo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308048/ https://www.ncbi.nlm.nih.gov/pubmed/32493844 http://dx.doi.org/10.1172/jci.insight.133434 |
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