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Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

Millions of naïve T cells with different TCRs may interact with a peptide-MHC ligand, but very few will activate. Remarkably, this fine control is orchestrated using a limited set of intracellular machinery. It remains unclear whether changes in stimulation strength alter the programme of signalling...

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Detalles Bibliográficos
Autores principales:	Ma, Claire Y, Marioni, John C, Griffiths, Gillian M, Richard, Arianne C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308083/ https://www.ncbi.nlm.nih.gov/pubmed/32412411 http://dx.doi.org/10.7554/eLife.53948

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