Aberrant subchondral osteoblastic metabolism modifies Na(V)1.8 for osteoarthritis

Pain is the most prominent symptom of osteoarthritis (OA) progression. However, the relationship between pain and OA progression remains largely unknown. Here we report osteoblast secret prostaglandin E2 (PGE2) during aberrant subchondral bone remodeling induces pain and OA progression in mice. Spec...

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Detalles Bibliográficos
Autores principales: Zhu, Jianxi, Zhen, Gehua, An, Senbo, Wang, Xiao, Wan, Mei, Li, Yusheng, Chen, Zhiyong, Guan, Yun, Dong, Xinzhong, Hu, Yihe, Cao, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308086/
https://www.ncbi.nlm.nih.gov/pubmed/32441256
http://dx.doi.org/10.7554/eLife.57656

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