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The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information

Our decisions often balance what we observe and what we desire. A prime candidate for implementing this complex balancing act is the basal ganglia pathway, but its roles have not yet been examined experimentally in detail. Here, we show that a major input station of the basal ganglia, the caudate nu...

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Autores principales: Doi, Takahiro, Fan, Yunshu, Gold, Joshua I, Ding, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308093/
https://www.ncbi.nlm.nih.gov/pubmed/32568068
http://dx.doi.org/10.7554/eLife.56694
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author Doi, Takahiro
Fan, Yunshu
Gold, Joshua I
Ding, Long
author_facet Doi, Takahiro
Fan, Yunshu
Gold, Joshua I
Ding, Long
author_sort Doi, Takahiro
collection PubMed
description Our decisions often balance what we observe and what we desire. A prime candidate for implementing this complex balancing act is the basal ganglia pathway, but its roles have not yet been examined experimentally in detail. Here, we show that a major input station of the basal ganglia, the caudate nucleus, plays a causal role in integrating uncertain visual evidence and reward context to guide adaptive decision-making. In monkeys making saccadic decisions based on motion cues and asymmetric reward-choice associations, single caudate neurons encoded both sources of information. Electrical microstimulation at caudate sites during motion viewing affected the monkeys’ decisions. These microstimulation effects included coordinated changes in multiple computational components of the decision process that mimicked the monkeys’ similarly coordinated voluntary strategies for balancing visual and reward information. These results imply that the caudate nucleus plays causal roles in coordinating decision processes that balance external evidence and internal preferences.
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spelling pubmed-73080932020-06-23 The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information Doi, Takahiro Fan, Yunshu Gold, Joshua I Ding, Long eLife Neuroscience Our decisions often balance what we observe and what we desire. A prime candidate for implementing this complex balancing act is the basal ganglia pathway, but its roles have not yet been examined experimentally in detail. Here, we show that a major input station of the basal ganglia, the caudate nucleus, plays a causal role in integrating uncertain visual evidence and reward context to guide adaptive decision-making. In monkeys making saccadic decisions based on motion cues and asymmetric reward-choice associations, single caudate neurons encoded both sources of information. Electrical microstimulation at caudate sites during motion viewing affected the monkeys’ decisions. These microstimulation effects included coordinated changes in multiple computational components of the decision process that mimicked the monkeys’ similarly coordinated voluntary strategies for balancing visual and reward information. These results imply that the caudate nucleus plays causal roles in coordinating decision processes that balance external evidence and internal preferences. eLife Sciences Publications, Ltd 2020-06-22 /pmc/articles/PMC7308093/ /pubmed/32568068 http://dx.doi.org/10.7554/eLife.56694 Text en © 2020, Doi et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Doi, Takahiro
Fan, Yunshu
Gold, Joshua I
Ding, Long
The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
title The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
title_full The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
title_fullStr The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
title_full_unstemmed The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
title_short The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
title_sort caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308093/
https://www.ncbi.nlm.nih.gov/pubmed/32568068
http://dx.doi.org/10.7554/eLife.56694
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