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The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
Our decisions often balance what we observe and what we desire. A prime candidate for implementing this complex balancing act is the basal ganglia pathway, but its roles have not yet been examined experimentally in detail. Here, we show that a major input station of the basal ganglia, the caudate nu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308093/ https://www.ncbi.nlm.nih.gov/pubmed/32568068 http://dx.doi.org/10.7554/eLife.56694 |
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author | Doi, Takahiro Fan, Yunshu Gold, Joshua I Ding, Long |
author_facet | Doi, Takahiro Fan, Yunshu Gold, Joshua I Ding, Long |
author_sort | Doi, Takahiro |
collection | PubMed |
description | Our decisions often balance what we observe and what we desire. A prime candidate for implementing this complex balancing act is the basal ganglia pathway, but its roles have not yet been examined experimentally in detail. Here, we show that a major input station of the basal ganglia, the caudate nucleus, plays a causal role in integrating uncertain visual evidence and reward context to guide adaptive decision-making. In monkeys making saccadic decisions based on motion cues and asymmetric reward-choice associations, single caudate neurons encoded both sources of information. Electrical microstimulation at caudate sites during motion viewing affected the monkeys’ decisions. These microstimulation effects included coordinated changes in multiple computational components of the decision process that mimicked the monkeys’ similarly coordinated voluntary strategies for balancing visual and reward information. These results imply that the caudate nucleus plays causal roles in coordinating decision processes that balance external evidence and internal preferences. |
format | Online Article Text |
id | pubmed-7308093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-73080932020-06-23 The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information Doi, Takahiro Fan, Yunshu Gold, Joshua I Ding, Long eLife Neuroscience Our decisions often balance what we observe and what we desire. A prime candidate for implementing this complex balancing act is the basal ganglia pathway, but its roles have not yet been examined experimentally in detail. Here, we show that a major input station of the basal ganglia, the caudate nucleus, plays a causal role in integrating uncertain visual evidence and reward context to guide adaptive decision-making. In monkeys making saccadic decisions based on motion cues and asymmetric reward-choice associations, single caudate neurons encoded both sources of information. Electrical microstimulation at caudate sites during motion viewing affected the monkeys’ decisions. These microstimulation effects included coordinated changes in multiple computational components of the decision process that mimicked the monkeys’ similarly coordinated voluntary strategies for balancing visual and reward information. These results imply that the caudate nucleus plays causal roles in coordinating decision processes that balance external evidence and internal preferences. eLife Sciences Publications, Ltd 2020-06-22 /pmc/articles/PMC7308093/ /pubmed/32568068 http://dx.doi.org/10.7554/eLife.56694 Text en © 2020, Doi et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Doi, Takahiro Fan, Yunshu Gold, Joshua I Ding, Long The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information |
title | The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information |
title_full | The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information |
title_fullStr | The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information |
title_full_unstemmed | The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information |
title_short | The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information |
title_sort | caudate nucleus contributes causally to decisions that balance reward and uncertain visual information |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308093/ https://www.ncbi.nlm.nih.gov/pubmed/32568068 http://dx.doi.org/10.7554/eLife.56694 |
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