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Intronic Variants in OCT1 are Associated with All-Cause and Cardiovascular Mortality in Metformin Users with Type 2 Diabetes

PURPOSE: Organic cation transporters (Octs) use cations like endogenous compounds, toxins, and drugs, such as metformin, as substrates. Therefore, these proteins determine the pharmacokinetics and -dynamics of metformin and thus its efficacy. Of note, metformin is today the most commonly used pharma...

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Detalles Bibliográficos
Autores principales:	Schweighofer, Natascha, Genser, Bernd, Maerz, Winfried, Kleber, Marcus E, Trummer, Olivia, Pieber, Thomas R, Obermayer-Pietsch, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308180/ https://www.ncbi.nlm.nih.gov/pubmed/32606866 http://dx.doi.org/10.2147/DMSO.S235663

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