Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells

Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat shock factor 1 (HSF1) binds to sequences located in the intron(s) of the PMAIP1 (NOXA) gene and upregulates its expression which induces apopt...

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Autores principales: Janus, Patryk, Toma-Jonik, Agnieszka, Vydra, Natalia, Mrowiec, Katarzyna, Korfanty, Joanna, Chadalski, Marek, Widłak, Piotr, Dudek, Karolina, Paszek, Anna, Rusin, Marek, Polańska, Joanna, Widłak, Wiesława
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308270/
https://www.ncbi.nlm.nih.gov/pubmed/31996779
http://dx.doi.org/10.1038/s41418-020-0501-8
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author Janus, Patryk
Toma-Jonik, Agnieszka
Vydra, Natalia
Mrowiec, Katarzyna
Korfanty, Joanna
Chadalski, Marek
Widłak, Piotr
Dudek, Karolina
Paszek, Anna
Rusin, Marek
Polańska, Joanna
Widłak, Wiesława
author_facet Janus, Patryk
Toma-Jonik, Agnieszka
Vydra, Natalia
Mrowiec, Katarzyna
Korfanty, Joanna
Chadalski, Marek
Widłak, Piotr
Dudek, Karolina
Paszek, Anna
Rusin, Marek
Polańska, Joanna
Widłak, Wiesława
author_sort Janus, Patryk
collection PubMed
description Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat shock factor 1 (HSF1) binds to sequences located in the intron(s) of the PMAIP1 (NOXA) gene and upregulates its expression which induces apoptosis. Such a mode of PMAIP1 activation is not dependent on p53. Therefore, HSF1 not only can activate the expression of genes encoding cytoprotective heat shock proteins, which prevents apoptosis, but it can also positively regulate the proapoptotic PMAIP1 gene, which facilitates cell death. This could be the primary cause of hyperthermia-induced elimination of heat-sensitive cells, yet other pro-death mechanisms might also be involved.
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spelling pubmed-73082702020-06-23 Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells Janus, Patryk Toma-Jonik, Agnieszka Vydra, Natalia Mrowiec, Katarzyna Korfanty, Joanna Chadalski, Marek Widłak, Piotr Dudek, Karolina Paszek, Anna Rusin, Marek Polańska, Joanna Widłak, Wiesława Cell Death Differ Article Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat shock factor 1 (HSF1) binds to sequences located in the intron(s) of the PMAIP1 (NOXA) gene and upregulates its expression which induces apoptosis. Such a mode of PMAIP1 activation is not dependent on p53. Therefore, HSF1 not only can activate the expression of genes encoding cytoprotective heat shock proteins, which prevents apoptosis, but it can also positively regulate the proapoptotic PMAIP1 gene, which facilitates cell death. This could be the primary cause of hyperthermia-induced elimination of heat-sensitive cells, yet other pro-death mechanisms might also be involved. Nature Publishing Group UK 2020-01-29 2020-07 /pmc/articles/PMC7308270/ /pubmed/31996779 http://dx.doi.org/10.1038/s41418-020-0501-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Janus, Patryk
Toma-Jonik, Agnieszka
Vydra, Natalia
Mrowiec, Katarzyna
Korfanty, Joanna
Chadalski, Marek
Widłak, Piotr
Dudek, Karolina
Paszek, Anna
Rusin, Marek
Polańska, Joanna
Widłak, Wiesława
Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells
title Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells
title_full Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells
title_fullStr Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells
title_full_unstemmed Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells
title_short Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells
title_sort pro-death signaling of cytoprotective heat shock factor 1: upregulation of noxa leading to apoptosis in heat-sensitive cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308270/
https://www.ncbi.nlm.nih.gov/pubmed/31996779
http://dx.doi.org/10.1038/s41418-020-0501-8
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