Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA(A) receptors

Brain GABA(Α) receptors are ionotropic receptors belonging to the class of Cys-loop receptors and are important drug targets for the treatment of anxiety and sleep disorders. By screening a compound library (2,112 compounds) at recombinant human α(4)β(1)δ GABA(Α) receptors heterologously expressed i...

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Detalles Bibliográficos
Autores principales: Falk-Petersen, Christina Birkedahl, Tsonkov, Tsonko M., Nielsen, Malene Sofie, Harpsøe, Kasper, Bundgaard, Christoffer, Frølund, Bente, Kristiansen, Uffe, Gloriam, David E., Wellendorph, Petrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308271/
https://www.ncbi.nlm.nih.gov/pubmed/32572053
http://dx.doi.org/10.1038/s41598-020-66821-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308271/
https://www.ncbi.nlm.nih.gov/pubmed/32572053
http://dx.doi.org/10.1038/s41598-020-66821-0

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