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Chimeric design of pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion

An orthogonal aminoacyl-tRNA synthetase/tRNA pair is a crucial prerequisite for site-specific incorporation of unnatural amino acids. Due to its high codon suppression efficiency and full orthogonality, the pyrrolysyl-tRNA synthetase/pyrrolysyl-tRNA pair is currently the ideal system for genetic cod...

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Detalles Bibliográficos
Autores principales:	Ding, Wenlong, Zhao, Hongxia, Chen, Yulin, Zhang, Bin, Yang, Yang, Zang, Jia, Wu, Jing, Lin, Shixian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308279/ https://www.ncbi.nlm.nih.gov/pubmed/32572025 http://dx.doi.org/10.1038/s41467-020-16898-y

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