Cargando…
The Impact of Trimetazidine on Disease Severity and Quality of Life in Parkinson’s Disease
Trimetazidine is contraindicated in movement disorders, however, a not negligible part of trimetazidine users is still patients with Parkinson’s disease (PD). The present study aimed to objectively determine the impact of trimetazidine on the severity of symptoms and the health-related quality of li...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308301/ https://www.ncbi.nlm.nih.gov/pubmed/32572075 http://dx.doi.org/10.1038/s41598-020-66692-5 |
_version_ | 1783548961453244416 |
---|---|
author | Pintér, Dávid Juhász, Annamária Harmat, Márk Janszky, József Kovács, Norbert |
author_facet | Pintér, Dávid Juhász, Annamária Harmat, Márk Janszky, József Kovács, Norbert |
author_sort | Pintér, Dávid |
collection | PubMed |
description | Trimetazidine is contraindicated in movement disorders, however, a not negligible part of trimetazidine users is still patients with Parkinson’s disease (PD). The present study aimed to objectively determine the impact of trimetazidine on the severity of symptoms and the health-related quality of life of patients with PD by measuring changes after its withdrawal. A consecutive series of 42 patients with PD using trimetazidine underwent detailed neurological and neuropsychological assessments at baseline and three months after the discontinuation of trimetazidine. Clinically relevant improvements were achieved with discontinuation of trimetazidine according to changes in scores of each part of the Movement Disorder Society-sponsored Unified Parkinson’s Disease Rating Scale (Part I: −25.7%, p < 0.001; Part II: −23.8%, p < 0.001; Part III: −28.5%, p < 0.001; Part IV: −30.1%, p = 0.004) and total scores of the Non-Motor Symptoms Scale (−25.6%, p = 0.004) and the Montgomery-Asberg-Depression Rating Scale (−20.1%, p = 0.001). Benefits resulting from the withdrawal of the drug also manifested in the improvement of the health-related quality of life based on changes in the summary index of the 39-item Parkinson’s Disease Questionnaire (−18.2%, p = 0.031). Our results provide clinical rationale for strictly avoiding the use of trimetazidine in PD. Discontinuation of trimetazidin results in clinically relevant improvements in Parkinsonian symptoms. |
format | Online Article Text |
id | pubmed-7308301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73083012020-06-23 The Impact of Trimetazidine on Disease Severity and Quality of Life in Parkinson’s Disease Pintér, Dávid Juhász, Annamária Harmat, Márk Janszky, József Kovács, Norbert Sci Rep Article Trimetazidine is contraindicated in movement disorders, however, a not negligible part of trimetazidine users is still patients with Parkinson’s disease (PD). The present study aimed to objectively determine the impact of trimetazidine on the severity of symptoms and the health-related quality of life of patients with PD by measuring changes after its withdrawal. A consecutive series of 42 patients with PD using trimetazidine underwent detailed neurological and neuropsychological assessments at baseline and three months after the discontinuation of trimetazidine. Clinically relevant improvements were achieved with discontinuation of trimetazidine according to changes in scores of each part of the Movement Disorder Society-sponsored Unified Parkinson’s Disease Rating Scale (Part I: −25.7%, p < 0.001; Part II: −23.8%, p < 0.001; Part III: −28.5%, p < 0.001; Part IV: −30.1%, p = 0.004) and total scores of the Non-Motor Symptoms Scale (−25.6%, p = 0.004) and the Montgomery-Asberg-Depression Rating Scale (−20.1%, p = 0.001). Benefits resulting from the withdrawal of the drug also manifested in the improvement of the health-related quality of life based on changes in the summary index of the 39-item Parkinson’s Disease Questionnaire (−18.2%, p = 0.031). Our results provide clinical rationale for strictly avoiding the use of trimetazidine in PD. Discontinuation of trimetazidin results in clinically relevant improvements in Parkinsonian symptoms. Nature Publishing Group UK 2020-06-22 /pmc/articles/PMC7308301/ /pubmed/32572075 http://dx.doi.org/10.1038/s41598-020-66692-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pintér, Dávid Juhász, Annamária Harmat, Márk Janszky, József Kovács, Norbert The Impact of Trimetazidine on Disease Severity and Quality of Life in Parkinson’s Disease |
title | The Impact of Trimetazidine on Disease Severity and Quality of Life in Parkinson’s Disease |
title_full | The Impact of Trimetazidine on Disease Severity and Quality of Life in Parkinson’s Disease |
title_fullStr | The Impact of Trimetazidine on Disease Severity and Quality of Life in Parkinson’s Disease |
title_full_unstemmed | The Impact of Trimetazidine on Disease Severity and Quality of Life in Parkinson’s Disease |
title_short | The Impact of Trimetazidine on Disease Severity and Quality of Life in Parkinson’s Disease |
title_sort | impact of trimetazidine on disease severity and quality of life in parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308301/ https://www.ncbi.nlm.nih.gov/pubmed/32572075 http://dx.doi.org/10.1038/s41598-020-66692-5 |
work_keys_str_mv | AT pinterdavid theimpactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease AT juhaszannamaria theimpactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease AT harmatmark theimpactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease AT janszkyjozsef theimpactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease AT kovacsnorbert theimpactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease AT pinterdavid impactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease AT juhaszannamaria impactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease AT harmatmark impactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease AT janszkyjozsef impactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease AT kovacsnorbert impactoftrimetazidineondiseaseseverityandqualityoflifeinparkinsonsdisease |