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The lateral septum mediates kinship behavior in the rat
Evolutionary theory and behavioral biology suggest that kinship is an organizing principle of social behavior. The neural mechanisms that mediate kinship behavior are, however, not known. Experiments confirm a sibling-approach preference in young rat pups and a sibling-avoidance-preference in older...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308382/ https://www.ncbi.nlm.nih.gov/pubmed/32572024 http://dx.doi.org/10.1038/s41467-020-16489-x |
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author | Clemens, Ann M. Wang, Hong Brecht, Michael |
author_facet | Clemens, Ann M. Wang, Hong Brecht, Michael |
author_sort | Clemens, Ann M. |
collection | PubMed |
description | Evolutionary theory and behavioral biology suggest that kinship is an organizing principle of social behavior. The neural mechanisms that mediate kinship behavior are, however, not known. Experiments confirm a sibling-approach preference in young rat pups and a sibling-avoidance-preference in older pups. Lesions of the lateral septum eliminate such kin preferences. In vivo juxta-cellular and whole-cell patch-clamp recordings in the lateral septum show multisensory neuronal responses to kin and non-kin stimuli. Non-kin odor-responsive neurons are located dorsally and kin-odor responsive neurons are located ventrally in the lateral septum. With development, the fraction of kin-responsive lateral septal neurons decrease and ongoing firing rates increase. Lesion effects, developmental changes and the ordered representation of response preferences according to kinship—an organization we refer to as nepotopy—point to a key role of the lateral septum in organizing mammalian kinship behavior. |
format | Online Article Text |
id | pubmed-7308382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73083822020-06-26 The lateral septum mediates kinship behavior in the rat Clemens, Ann M. Wang, Hong Brecht, Michael Nat Commun Article Evolutionary theory and behavioral biology suggest that kinship is an organizing principle of social behavior. The neural mechanisms that mediate kinship behavior are, however, not known. Experiments confirm a sibling-approach preference in young rat pups and a sibling-avoidance-preference in older pups. Lesions of the lateral septum eliminate such kin preferences. In vivo juxta-cellular and whole-cell patch-clamp recordings in the lateral septum show multisensory neuronal responses to kin and non-kin stimuli. Non-kin odor-responsive neurons are located dorsally and kin-odor responsive neurons are located ventrally in the lateral septum. With development, the fraction of kin-responsive lateral septal neurons decrease and ongoing firing rates increase. Lesion effects, developmental changes and the ordered representation of response preferences according to kinship—an organization we refer to as nepotopy—point to a key role of the lateral septum in organizing mammalian kinship behavior. Nature Publishing Group UK 2020-06-22 /pmc/articles/PMC7308382/ /pubmed/32572024 http://dx.doi.org/10.1038/s41467-020-16489-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Clemens, Ann M. Wang, Hong Brecht, Michael The lateral septum mediates kinship behavior in the rat |
title | The lateral septum mediates kinship behavior in the rat |
title_full | The lateral septum mediates kinship behavior in the rat |
title_fullStr | The lateral septum mediates kinship behavior in the rat |
title_full_unstemmed | The lateral septum mediates kinship behavior in the rat |
title_short | The lateral septum mediates kinship behavior in the rat |
title_sort | lateral septum mediates kinship behavior in the rat |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308382/ https://www.ncbi.nlm.nih.gov/pubmed/32572024 http://dx.doi.org/10.1038/s41467-020-16489-x |
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